关键词: 结核, 肺/病理生理学, 超氧化物歧化酶, 谷胱甘肽过氧化酶, 丙二醛

Abstract: ObjectiveTo study the characteristic and influential factors of imbalance between oxidation and anti-oxidation of pulmonary tuberculosis(TB). MethodsThe superoxide dismutase (SOD)，glutathione peroxidase (GPX) and malonaldehyde(MDA) were detected in the sera from 20 healthy controls and 120 patients with pulmonary TB. Results1. Compared with the healthy controls, the level of SOD，GPX decreased and MDA increased in pulmonary TB group(P＜0.01). 2. The SOD，GPX decreased more obviously in the pulmonary TB patients with cavity or fibrosis and in the patients of faster erythrocyte sedimentation rate(P＜0.01)，but no difference of MDA was observed between them. 3.Through the chi-square test and logistic regression, we found that the loss of SOD and GPX was associated with TB lesion’s imageological characteristic and the patients’ESR. ConclusionsThe patients with TB have the imbalance between oxidation and anti-oxidation， the loss of SOD and GPX was associated with TB lesion’s imageological characteristic and the patients’ESR.

Key words: tuberculosis,pulmonary/pathophysiology, superoxide dismutase, glutathione peroxidase, malondialdehyde