甘肃省临夏州、甘南州、定西市结核病耐药监测结果分析

中国防痨杂志 ›› 2009, Vol. 31 ›› Issue (4): 206-209.

甘肃省临夏州、甘南州、定西市结核病耐药监测结果分析

司红艳¹；李晴¹；穆洮俊¹；梁成智²；杨巧铃³；谢仲科⁴；马玲¹

１.甘肃省CDC结核病防治所兰州730030；２.定西市CDC结核病防治所定西743000；３.甘南州CDC结核病防治所甘南730030； 4.临夏州CDC结核病防治所临夏731100

出版日期:2009-04-10 发布日期:2011-11-03

Analysis of anti-TB drug resistance surveillance in Linxia, Ganan and Dingxi in Gansu province

Si Hongyan¹, Li Qing1, Mu Taojun¹, Liang Chengzhi², Yang Qiaoling³, Xie Zhongke⁴, Ma Ling¹

1.Tuberculosis Control and Prevention Institute of Gansu Center for Disease Control and Prevention, Lanzhou, 730020 China; 2.Tuberculosis Control and Prevention Institute of Dingxi Center for Disease Control and Prevention, Dingxi 743000, China; 3.Tuberculosis Control and Prevention Institute of Gannan Center for Disease Control and Prevention, Gannan 730030, China; 4.Tuberculosis Control and Prevention Institute of Linxia Center for Disease Control and Prevention, Linxia 731100, China

Online:2009-04-10 Published:2011-11-03

摘要/Abstract

摘要： 目的了解甘肃省临夏回族自治州、甘南藏族自治州、定西市结核分枝杆菌的耐药现状及耐多药情况,为甘肃省少数民族及贫困地区结核病防治提供科学依据。方法依据(WHO/ IUATLD)结核病耐药监测指南，将调查地区1年连续新发涂阳病人和同期新登记的复治涂阳病人作为监测病例，对成功分离的909例结核分枝杆菌菌株，用绝对浓度间接法进行药物敏感性实验。结果总耐药率26.0%，初始耐药率21.0%，获得性耐药率50.0%；耐多药率10.1%，其中初始耐多药率为7%，获得性耐多药率为24.1%；耐利福平菌株中有70.8%是耐多药（MDR-TB）菌株。结论甘肃省少数民族结核分枝杆菌的耐药的发生率较高,耐药现状应引起卫生主管部门及各级结核病防治机构的重视。

关键词: 分枝杆菌, 结核, 抗药性, 细菌, 甘肃省

Abstract: ObjectiveTo find out the status of drug resistance (DR) of Mycobacterium tuberculosis and multi drug-resistance tuberculosis (MDR-TB) situation in Linxia, Gannan and Dingxi in Gansu province, and to provide scientific evidence for TB control in minority and poor area. MethodsAccording to the guidelines for Surveillance of Drug Resistance in Tuberculosis (WHO/ IUATLD), all new smear positive cases and new registered retreatment smear positive cases in one year in survey area were the cases for surveillance. A total of 909 isolated strains of Mycobacterium tuberculosis were tested for drug susceptibility by the absolute concentration method. ResultsThe overall drug resistance was 26.0%, the primary drug resistance was 21.0% and the acquired drug resistance was 50.0%; multi-drug resistance was 10.1%, the rates were 7% and 24.1% respectively for primary multi-drug resistance and acquired multi-drug resistance; 70.8% RFP-resistant strains were MDR-TB strains. ConclusionThe incidence of drug resistance of Mycobacterium tuberculosis in minority in Gansu province is high, health administrative department and TB control institute at each level should pay attention to drug resistance.

Key words: Mycobacterium tuberculosis, drug resistance,bacterial, Gansu province

司红艳,李晴,穆洮俊,梁成智,杨巧铃,谢仲科,马玲. 甘肃省临夏州、甘南州、定西市结核病耐药监测结果分析[J]. 中国防痨杂志, 2009, 31(4): 206-209.

Si Hongyan¹, Li Qing1, Mu Taojun¹, Liang Chengzhi², Yang Qiaoling³, Xie Zhongke⁴, Ma Ling¹. Analysis of anti-TB drug resistance surveillance in Linxia, Ganan and Dingxi in Gansu province[J]. Chinese Journal of Antituberculosis, 2009, 31(4): 206-209.

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