Email Alert | RSS    帮助

中国防痨杂志 ›› 2008, Vol. 30 ›› Issue (4): 279-282.

• 论著 • 上一篇    下一篇

62例成人脊髓型结核性脑膜炎临床分析

韩利军;闫世明;郭子源;李欢   

  1. 长春市传染病医院 长春 130123
  • 出版日期:2008-04-10 发布日期:2011-11-03

Clinical analysis of 62 cases with myeloid form tubercular meningitis in adult

Han Lijun,Yan Shiming,Guo Ziyuan,et al.   

  1. Changchun Infectious Hospital,changchun 130123,China
  • Online:2008-04-10 Published:2011-11-03

摘要: 目的探讨成人脊髓型结核性脑膜炎(结脑)的临床特点和治疗方法。方法对1999—2004年收治确诊的62例成人脊髓型结脑进行回顾性分析。结果脊髓型结脑占同期住院结脑13.9%,除具有发热及脑膜刺激征外,以截瘫、尿便障碍和传导束型感觉障碍为主要表现。脑脊液循环通路存在不同程度梗阻,脑脊液常规生化并非完全符合蛋白细胞分离现象,ADA活性明显升高,虽然细胞学呈混合性细胞反应,但是嗜中性粒细胞比例较低,平均仅为17.7%,尿便障碍较截瘫恢复早,治愈率为61.3%,病死率为3.2%,后遗症发生率为35.5%,复发率为1.6%。结论脊髓型结脑治愈率低,后遗症发生率高。结脑早期发现和有效治疗可有效预防一部分脊髓型结脑的发生,以H、R、S(E)、Z为主的四联18~24个月抗结核治疗方案适用于脊髓型结脑,适宜剂量地塞米松和长疗程的放脑脊液并鞘内注药治疗可以提高脊髓型结脑的治愈率。

关键词: 脊髓, 结核,脑膜

Abstract: Objective To discuss the clinical feature and treatment method of myeloid form tubercular meningitis(TBM) in adult. Methods To retrospectively analyze the 62 cases myeloid form tubercular meningitis in adult from 1999 to 2004. Results The percentage of myeloid form tubercular meningitis to tubercular meningitis in corresponding period patients was 13.9%.Main clinical manifestation were paraplegia,urination disorder and dysporia,disturbance of sensation result of conduction tract besides fever and meninges irritation symptom.Cerebrospinal fluid(CSF) circulation circuit was obstructed at various degree and CSF routine and biochemistry was not fully corresponding with albuminocytologic dissociation phenomenon and ADA activity rises obviously,cytology presents mix cell changed,but the percentage of neutrophil was relatively low,the average rate was 17.7%.Urination disorder and dysporia resumed earlier than paraplegia and the cure rate was 61.3%,case-fatality rate was 3.2%,the sequela rate was 35.5%,the recuring rate was 1.6%. Conclusion The cure rate of myeloid form tubercular meningitis is low and the sequela rate is high.Early discovery and effective treatment can prevent partly myeloid form tubercular meningitis.Anti-tubercular therapeutic schedule with mainly H,R,S(E),Z combined through 18~24 months apply to myeloid form tubercular meningitis,and feasible dose dexamethasone and long-period releasing cerebrospinal fluid combined with intrathecal injection can raise the cure rate of myeloid form tubercular meningitis.

Key words: myeloid form, tuberculosis,meninges