关键词: 结核,肺/药物疗法, 不良反应

Abstract: Objective To find out the occurring of the adverse reactions of the first-line anti-tuberculosis drugs in Beijing and its influence on the chemotherapy. Methods All pulmonary tuberculosis patients who come from five districts include the urban area,the suburbs and the outer suburbs were treated with the first-line standard regimen from July 2006 to January 2007.And the prospective study was used to observe their abnormal clinical reaction,the liver and the kidney function and the blood routine during the chemotherapy.The evaluation on the abnormal which were related,make "affirmation" and "in all probability" as the side effects. Results The patients who occurred side effects from this group of anti-TB drugs were 188,which accounted for 34.9%.Among these patients,the mild were 78,accounted for 14.5%,the moderate were 106,accounted for 19.3%,and the serious were 6,accounted for 1.11%.78 patients were resulted in modification or discontinuation of therapy,which accounted for 14.5%. Conclusions The incidence of the first-line anti-tuberculosis drugs which used in the standard regimen in Beijing is relatively high,influencing on the chemotherapy at a certain extent.We should pay more attention to the hepatotoxicity,which is more significant during all the side effects.We should also perfect the definition of the hepatotoxicity and the principle of disposal.

Key words: pulmonary tuberculosis/chemotherapy, adverse reactions of drugs