含结核清和含对氨基水杨酸钠方案治疗耐多药肺结核疗效分析

中国防痨杂志 ›› 2001, Vol. 23 ›› Issue (1): 27-29.

含结核清和含对氨基水杨酸钠方案治疗耐多药肺结核疗效分析

赵一红；张振显；杜颖；

河南省南阳市结核病防治所 473068；

出版日期:2001-01-10 发布日期:2001-11-03

Therapeutic effects of containing DPC or PAS regimens on multi-drug resistant pulmonary tuberculosis

ZHAO Yi hong,ZHANG Zhen xian,DU Ying.

Tuberculosis Control Centre of Nanyang,Henan 473068

Online:2001-01-10 Published:2001-11-03

摘要/Abstract

摘要： 目的　考核结核清抗结核的疗效并寻求治疗耐多药肺结核合理有效的方法。方法选取39例耐多药肺结核患者,随机分为含结核清(DPC)组及含对氨基水杨酸钠(P)组。结果两组方案满疗程后痰菌阴转率分别为95%、93%。X线胸片吸收好转率均为86%。随访二年复发率分别为5%、8%。以上两组结果比较差异均无显著性(P>0.05)。但P费用比DPC高数倍且含DPC组胃肠道反应及静脉炎发生率远低于含P组(P<0.05)。结论 DPC、P分别配合K、O、TH、Z组成的治疗耐多药肺结核方案安全有效,适用于耐多药结核的治疗,含DPC组的2 KOTHZ DPC/6-10 OTHZ DPC方案口服给药、费用较含P组低、副作用小患者易接受,值得推广。

关键词: 结核清, 对氨基水杨酸钠, 结核,肺/药物治疗

Abstract: Objective To understand the therapeutic effects of containing DPC or PAS regimens on MDR pulmonary tuberculosis.Methods 39 cases of MDR pulm.tuberculosis are selected and divided randomly in DPC group and P group respectively.Results After complete the treatment course,the sputum negative conversion rate of above two groups was 95% and 93% respectively.The X Ray resolving rate were 86% equally.The relapse rate following 2 years follow-up were 5% and 8%.All above Results of two groups were no significant difference(P>0.05),but the occurence rate of gastrointestinal adverse reaction and phlebitis of group DPC was much lower than those of the P group(P< 0.05).Conclusion The antituberculosis regimen of DPC or PAS with K、O、TH and Z reparatively is an effective and safe approach for treating the multi drug resistant pulm.tuberculosis,especially the 2 KOTHZ DPC/6 10 OTHZ DPC regimen is cheap cost,less adverse reaction and easy to accept,therefore it is worth recommending.

Key words: Dipasic(DPC), Para aminosalicylic acid(PAS), Tuberculosis pulmonary/drug therapy

赵一红,张振显,杜颖,. 含结核清和含对氨基水杨酸钠方案治疗耐多药肺结核疗效分析[J]. 中国防痨杂志, 2001, 23(1): 27-29.

ZHAO Yi hong,ZHANG Zhen xian,DU Ying.. Therapeutic effects of containing DPC or PAS regimens on multi-drug resistant pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2001, 23(1): 27-29.