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中国防痨杂志 ›› 2014, Vol. 36 ›› Issue (10): 901-904.doi: 10.3969/j.issn.1000-6621.2014.10.009

• 论著 • 上一篇    下一篇

320层动态容积CT灌注成像应用于肺结核伴咯血的初步研究

渠海贤 敖国昆 袁小东 李强 谈志远 田媛   

  1. 100853 解放军总医院学员队(渠海贤);解放军第三O九医院放射科(敖国昆、袁小东、李强、谈志远、田媛)
  • 收稿日期:2014-01-21 出版日期:2014-10-10 发布日期:2014-11-01
  • 通信作者: 敖国昆 E-mail:aogk309@aliyun.com
  • 基金资助:

    首都临床特色应用研究专项(Z131107002213076);320排CT灌注成像对肺结核的临床应用研究(2014ZD-003)

The clinical research on the application of dual-input lung perfusion CT technique to tuberculosis hemoptysis

QU Hai-xian,AO Guo-kun,YUAN Xiao-dong,LI Qiang,TAN Zhi-yuan, TIAN Yuan   

  1. Students’Party, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
  • Received:2014-01-21 Online:2014-10-10 Published:2014-11-01
  • Contact: AO Guo-kun E-mail:aogk309@aliyun.com

摘要: 目的 通过与DSA血管造影对照,对320层CT肺双入口灌注成像技术(dual-input lung perfusion CT, DICTp)检出和定位肺结核伴咯血患者肺部血流动力学异常的准确性进行研究,以及研究异常灌注肺段数与咯血量的相关性。方法 本研究收集2013年1—12月解放军第三○九医院放射科收治的肺结核合并咯血患者,排除灌注图像移动伪影大、很少并发咯血的肺结核病理类型及最终诊断不明确者,共纳入31例患者。在支气管动脉栓塞术术前进行DICTp成像检查,后处理并记录各个肺段CT灌注参数,以数字减影血管造影(DSA)图像为诊断金标准,分析DICTp技术诊断肺部异常血流的准确性,并对异常灌注肺段数与咯血量作相关性分析。结果 31例患者共观察558个肺段,其中DSA造影发现异常肺段(有体循环动脉-肺动脉瘘)200个,DICTp检出异常灌注肺段209个,一致性检验Kappa系数为0.819>0.75,两者诊断效能一致性良好。DICTp成像以灌注指数(PI)为最有意义的诊断指标,当临界值为92.75时,敏感度为91.9%,特异度为89.6%。31例患者中10例发生大咯血,14例发生中量咯血,7例发生少量咯血,异常灌注肺段数2~14个;Spearman秩相关分析异常灌注肺段数与咯血量的相关系数为0.605,呈中度相关。结论 DICTp检出和定位肺结核大咯血患者肺部异常血流准确、敏感,且异常灌注肺段数与咯血级别呈中度相关。

关键词: 结核, 肺/放射摄影术, 结核, 肺/并发症, 咯血, 体层摄影术, X线计算机, 血流动力学

Abstract: Objective  In contrast to DSA angiography, we prospectively analyze the accuracy of the dual-input lung perfusion CT technique (DICTp) to detect and locate hemodynamic abnormalities in tuberculosis hemoptysis patients and the correlation between the abnormal perfusion lung segments and the amount of hemoptysis.  Methods  Thirty-one consecutive cases of patients with tuberculosis complicated with hemoptysis underwent dual-input lung perfusion CT scan just before DSA. And then, the CT perfusion parameters at every segment of lung were recorded and compared with those of DSA, supposing DSA diagnostic imaging as the gold standard.  Results  We observed 558 lung segments in the 31 cases and found 200 positive lung segments in DSA imaging. DICTp disco-vered all the 200 positive lung segments.We considered the perfusion index (PI) as the most significant indicator for the diagnosis. When the critical value is 92.75, the sensitivity is 91.9% and specificity is 89.6%. The number of abnormal perfusion lung segment and the level of hemoptysis show medium correlation and the correlation coefficient is 0.605.  Conclusion DICTp can detect and locate pulmonary abnormal blood flow in hemoptysis patients with tuberculosis accurately and sensitively and the number of abnormal perfusion lung segment and the level of hemoptysis show medium correlation.

Key words: Tuberculosis, pulmonary/radiography, Tuberculosis, pulmonary/complications, Hemoptysis, Tomography, X-ray computed, Hemodynamics