Global development trends and hotspots of researches on elderly tuberculosis, 2000—2025: a visualized bibliometric analysis

doi:10.19982/j.issn.1000-6621.20250202

Abstract

Abstract:

Objective: To analyze global development trends and hotspots of researches on elderly tuberculosis from 2000 to 2025 using bibliometric methods, aiming to provide references for future research and prevention strategies. Methods: Literature with topics of “tuberculosis” and “elderly” published between January 1, 2000, and March 10, 2025, was retrieved from the Web of Science Core Collection. A total of 4103 publications were identified, limited to “Article” and “Review” categories. VOSviewer 1.6.18, CiteSpace 6.1.R6, and Bibliometrix were applied to visualize publication output, distributions of country/region and institution, authors, journals, and keywords. Research hotspots and frontiers were further identified through burst keyword detection. Results: The annual number of publications on elderly tuberculosis increased from 50 in 2000 to 350 in 2024, showing a continuous upward trend, with an average annual growth rate of approximately 8.9%. The publications involved 167 countries/regions and 1442 journals. The top five productive countries were the United States (996), China (598), the United Kingdom (400), South Africa (332), and India (319), accounting for 64.3% of the total output. Highly productive institutions included the London School of Hygiene & Tropical Medicine (94), the University of Cape Town (91), and the University of the Witwatersrand (80). Keyword co-occurrence analysis revealed that research hotspots focused on the epidemiological characteristics of elderly tuberculosis, HIV co-infection and immunosenescence mechanisms, diagnostic technologies, and treatment optimization, with “immunosenescence” emerging as a recent research frontier. Conclusion: Research on elderly tuberculosis has remained active, but international collaboration and cross-disciplinary integration require further strengthening. Future studies should focus on immunosenescence mechanisms, rapid diagnostic techniques, and individualized prevention strategies to improve tuberculosis control among the elderly.

Key words: Mycobacterium tuberculosis, Aged, Bibliometrics, Journal article

CLC Number:

R52
R592

Wang Hangxing, Zhang Ning, Liu Xiaoqing, Kang Lin. Global development trends and hotspots of researches on elderly tuberculosis, 2000—2025: a visualized bibliometric analysis[J]. Chinese Journal of Antituberculosis, 2025, 47(10): 1365-1377. doi: 10.19982/j.issn.1000-6621.20250202

Figures/Tables 14

第一作者及文献出处	标题	期刊	年份	总被引次数	年均总被引频次
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators^[20]	Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990—2017: A systematic analysis for the Global Burden of Disease Study 2017	Lancet	2018	6470	808.75
GBD 2017 Causes of Death Collaborators^[21]	Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980—2017: A systematic analysis for the Global Burden of Disease Study 2017	Lancet	2018	3112	389.00
GBD 2016 Causes of Death Collaborators^[22]	Global, regional, and national age-sex specific mortality for 264 causes of death, 1980—2016: A systematic analysis for the Global Burden of Disease Study 2016	Lancet	2017	2493	277.00
GBD 2016 Alcohol Collaborators^[23]	Alcohol use and burden for 195 countries and territories, 1990—2016: a systematic analysis for the Global Burden of Disease Study 2016	Lancet	2018	2045	255.63
Ytterberg^[24]	Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis	N Engl J Med	2022	942	235.50
Krokstad^[25]	Cohort Profile: the HUNT Study, Norway	Int J Epidemiol	2013	862	66.31
Menzies^[26]	Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research	Ann Intern Med	2007	810	42.63
Saukkonen^[27]	An official ATS statement: hepatotoxicity of antituberculosis therapy	Am J Respir Crit Care Med	2006	788	39.40
Rajpurkar^[28]	Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists	PLoS Med	2018	699	87.38
Mangtani^[29]	Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials	Clin Infect Dis	2014	663	55.25

References 41

[1]	World Health Organization. Global tuberculosis report 2024. Geneva: World Health Organization, 2024.
[2]	陈钢, 屈燕, 李玉红, 等. 中国老年人结核病防治核心信息知晓率及影响因素分析. 中华流行病学杂志, 2024, 45(2): 237-241. doi:10.3760/cma.j.cn112338-20230606-00351.
[3]	Yan MA, Gao WW. Current situation and prospect of prevention and treatment among elderly tuberculosis. J Tuberc Lung Health, 2018, 7(3): 161-166. doi:10.3969/j.issn.2095-3755.2018.03.003.
[4]	Chakaya J, Khan M, Ntoumi F, et al. Global tuberculosis report 2020-Reflections on the Global TB burden, treatment and prevention efforts. Int J Infect Dis, 2021, 113(1): S7-S12. doi:10.1016/j.ijid.2021.02.107.
[5]	全国第五次结核病流行病学抽样调查技术指导组, 全国第五次结核病流行病学抽样调查办公室. 2010年全国第五次结核病流行病学抽样调查报告. 中国防痨杂志, 2012, 34(8): 485-508.
[6]	Li SJ, Li YF, Song WM, et al. Population aging and trends of pulmonary tuberculosis incidence in the elderly. BMC Infect Dis, 2021, 21(1): 302. doi:10.1186/s12879-021-05994-z.
[7]	Guthmann JP, Léon L, Antoine D, et al. Tuberculosis treatment outcomes of notified cases: Trends and determinants of potential unfavourable outcome, France, 2008 to 2014. Euro Surveill, 2020, 25(4):1900191. doi:10.2807/1560-7917.Es.2020.25.4.1900191.
[8]	Velayutham BR, Nair D, Chandrasekaran V, et al. Profile and response to anti-tuberculosis treatment among elderly tuberculosis patients treated under the TB Control programme in South India. PLoS One, 2014, 9(3): e88045. doi:10.1371/journal.pone.0088045.
[9]	Di Gennaro F, Vittozzi P, Gualano G, et al. Active pulmonary tuberculosis in elderly patients: A 2016—2019 retrospective analysis from an italian referral hospital. Antibiotics (Basel), 2020, 9(8): 489. doi:10.3390/antibiotics9080489.
[10]	Ananthakrishnan R, Kumar K, Ganesh M, et al. The profile and treatment outcomes of the older (aged 60 years and above) tuberculosis patients in Tamilnadu, South India. PLoS One, 2013, 8(7): e67288. doi:10.1371/journal.pone.0067288.
[11]	van Arkel C, Storms I, Kurver L, et al. Elderly patients with tuberculosis in a low-incidence country-Clinical characteristics, inflammation and outcome. J Infect, 2024, 89(2):106200. doi:10.1016/j.jinf.2024.106200.
[12]	Pu QH, Lyu QJ, Su HY. Bibliometric analysis of scientific publications in transplantation journals from Mainland China, Japan, South Korea and Taiwan between 2006 and 2015. BMJ Open, 2016, 6(8): e011623. doi:10.1136/bmjopen-2016-011623.
[13]	Mongeon P, Paul Hus A. The journal coverage of Web of Science and Scopus: a comparative analysis. Scientometrics, 2016, 106(1): 213-228. doi:10.1007/s11192-015-1765-5.
[14]	Walker B, Alavifard S, Roberts S, et al. Inter-rater reliability of h-index scores calculated by Web of Science and Scopus for clinical epidemiology scientists. Health Info Libr J, 2016, 33(2): 140-149. doi:10.1111/hir.12140. pmid: 27168256
[15]	Pu Y, Luo Y. Acute kidney injury in patients with cirrhosis: A bibliometric analysis based on Web of Science. Asian J Surg, 2024, 47(9): 4096-4097. doi:10.1016/j.asjsur.2024.05.042.
[16]	van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538. doi:10.1007/s11192-009-0146-3. pmid: 20585380
[17]	Chen CM, Hu ZG, Liu SB, et al. Emerging trends in regenerative medicine: A scientometric analysis in CiteSpace. Expert Opin Biol Th, 2012, 12(5): 593-608. doi:10.1517/14712598.2012.674507.
[18]	Tian YM, Liu JY, Xu X, et al. Knowledge mapping of vocational education and training research (2004—2020): A visual analysis based on CiteSpace. Sci Rep, 2023, 13(1):22348. doi:10.1038/s41598-023-49636-7.
[19]	Yang S, Luo J, Zou WW, et al. Research trends in vascular chips from 2012 to 2022: A bibliometrix and visualized analysis. Front Bioeng Biotechnol, 2024, 12: 1409467. doi:10.3389/fbioe.2024.1409467.
[20]	GBD 2017 Disease and Injury Incidence and Prevalence Colla-borators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990—2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1789-1858. doi:10.1016/s0140-6736(18)32279-7.
[21]	GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980—2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1736-1788. doi:10.1016/s0140-6736(18)32203-7.
[22]	GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980—2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1151-1210. doi:10.1016/s0140-6736(17)32152-9.
[23]	GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990—2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2018, 392(10152): 1015-1035. doi:10.1016/S0140-6736(18)31310-2.
[24]	Ytterberg SR, Bhatt DL, Mikuls TR, et al. Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. N Engl J Med, 2022, 386(4): 316-326. doi:10.1056/NEJMoa2109927.
[25]	Krokstad S, Langhammer A, Hveem K, et al. Cohort Profile: the HUNT Study, Norway. Int J Epidemiol, 2013, 42(4): 968-977. doi:10.1093/ije/dys095. pmid: 22879362
[26]	Menzies D, Pai M, Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med, 2007, 146(5): 340-354. doi:10.7326/0003-4819-146-5-200703060-00006. pmid: 17339619
[27]	Saukkonen JJ, Cohn DL, Jasmer RM, et al. An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med, 2006, 174(8): 935-952. doi:10.1164/rccm.200510-1666ST.
[28]	Rajpurkar P, Irvin J, Ball RL, et al. Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists. PLoS Med, 2018, 15(11): e1002686. doi:10.1371/journal.pmed.1002686.
[29]	Mangtani P, Abubakar I, Ariti C, et al. Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials. Clin Infect Dis, 2014, 58(4): 470-480. doi:10.1093/cid/cit790. pmid: 24336911
[30]	World Health Organization. Global tuberculosis report 2023. Geneva: World Health Organization, 2023.
[31]	World Health Organization. Global tuberculosis report 2021. Geneva: World Health Organization, 2021.
[32]	World Health Organization. Tuberculosis patient cost surveys: a handbook. Geneva: World Health Organization, 2017.
[33]	World Health Organization. Global tuberculosis report 2012. Geneva: World Health Organization, 2012.
[34]	Mishra A, George AA, Sahu KK, et al. Tuberculosis and COVID-19 Co-infection: An Updated Review. Acta Biomed, 2020, 92(1): e2021025. doi:10.23750/abm.v92i1.10738.
[35]	Gupta N, Ish P, Gupta A, et al. A profile of a retrospective cohort of 22 patients with COVID-19 and active/treated tuberculosis. Eur Respir J, 2020, 56(5):2003408. doi:10.1183/13993003.03408-2020.
[36]	Sarkar S, Khanna P, Singh AK. Impact of COVID-19 in patients with concurrent co-infections: A systematic review and meta-analyses. J Med Virol, 2021, 93(4): 2385-2395. doi:10.1002/jmv.26740. pmid: 33331656
[37]	Restrepo BI, Kleynhans L, Salinas AB, et al. Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups. Tuberculosis (Edinb), 2018, 113: 10-18. doi:10.1016/j.tube.2018.08.007.
[38]	Lienhardt C, Lönnroth K, Menzies D, et al. Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions. PLoS Med, 2016, 13(3): e1001965. doi:10.1371/journal.pmed.1001965.
[39]	Samarathunga T, Katulanda P. Medical research and publication in a national and international economic crisis. Ceylon J Med Sci, 2022, 59(1): 1-3. doi:10.4038/cjms.v59i1.5064.
[40]	Kranzer K, Afnan Holmes H, Tomlin K, et al. The benefits to communities and individuals of screening for active tuberculosis disease: a systematic review. Int J Tuberc Lung Dis, 2013, 17(4): 432-446. doi:10.5588/ijtld.12.0743. pmid: 23485377
[41]	Vieira LRC, Dávila ASV, Mayta Tovalino F. Scientometric analysis of Mycobacterium tuberculosis revaccination: Dynamics, impact and analysis of collaborative networks. Lung India, 2025, 42(1): 32-39. doi:10.4103/lungindia.lungindia_433_24.

排名	机构名称	发文量	构成比(%)
1	伦敦卫生与热带医学院	94	2.29
2	开普敦大学	91	2.22
3	威特沃特斯兰德大学	80	1.95
4	各国卫生部^a	64	1.56
5	约翰斯·霍普金斯大学	59	1.44
6	斯泰伦博斯大学	58	1.41
7	伦敦大学学院	57	1.39
8	美国疾病控制与预防中心	56	1.36
9	加州大学旧金山分校	48	1.17
10	哈佛医学院	47	1.15
11	中国疾病预防控制中心	45	1.10
12	夸祖鲁-纳塔尔大学	45	1.07
13	麦吉尔大学	44	1.05
14	首都医科大学	43	1.05
15	马凯雷雷大学	43	1.05
16	华盛顿大学	43	1.05
17	世界卫生组织(WHO)	40	0.97
18	中国台湾大学	39	0.95
19	伦敦帝国学院	38	0.93
20	英属哥伦比亚大学	36	0.88

排序	期刊	发文量	国家	2023年影响因子(IF)	2022年 JCR分区
1	PLoS One	215	美国	2.9	Q1
2	International Journal of Tuberculosis and Lung Disease	166	法国	3.8	Q2
3	BMC Infectious Diseases	105	英国	3.4	Q2
4	BMC Public Health	56	英国	3.5	Q1
5	Clinical Infectious Diseases	54	美国	8.2	Q1
6	Cureus	45	美国	1.0	Q3
7	Scientific Reports	44	英国	3.8	Q1
8	Frontiers in Public Health	39	瑞士	3.0	Q2
9	BMJ Open	37	英国	2.4	Q1
10	Medicine (Baltimore)	34	美国	1.4	Q2