Research and development/exploitation of therapeutic drugs for NTM pulmonary disease:present situation and challenges

doi:10.3969/j.issn.1000-6621.2021.07.015

Abstract

Abstract:

Non-tuberculous mycobacteria (NTM) belongs to the genus mycobacterium,which is “close relative” to Mycobacterium tuberculosis. In recent years, the prevalence of chronic lung diseases caused by NTM is increasing at an alarming rate, even exceeding Mycobacterium tuberculosis in some countries. At present, the clinical treatment mainly relies on long-term therapy with combined medication, but the results are often unsatisfactory. Therefore, there is an urgent need for noval and more effective antimicrobials as well as new chemotherapy regimen. This article reviews the current situation and challenges in NTM drug development, in order to provide new insight for the treatment of NTM pulmonary disease.

Key words: Mycobacterium infections, atypical, Antitubercular agents, Review literature as topic

ZHENG Lu-yao, LU Yu, CHEN Xiao-you. Research and development/exploitation of therapeutic drugs for NTM pulmonary disease:present situation and challenges[J]. Chinese Journal of Antituberculosis, 2021, 43(7): 729-734. doi: 10.3969/j.issn.1000-6621.2021.07.015

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