Association of IL-2-330T/G and IL-6-174G/C polymorphisms with tuberculosis susceptibility: a Meta-analysis

doi:10.3969/j.issn.1000-6621.2018.03.010

Abstract

Abstract:

Objective To investigate the relationship between interleukin-2 (IL-2-330T/G) and interleukin-6 (IL-6-174G/C) gene polymorphisms and susceptibility of tuberculosis (TB).Methods Relevant English and Chinese publications were identified by a literature search in the PubMed, Medline, EMBase, Web of Science, Elsevier Science Direct, Wanfang Data, CNKI and Weipu databases from January 1990 to June 2017. Two investigators screened 573 articles, and 12 articles were finally included according to the inclusion and exclusion criteria. Meta-analysis was performed on the original data by using Stata 12.0.Results In all, eight studies containing 971 cases and 1519 controls were used to assess the potential influence of the IL-2-330T/G polymorphism with TB susceptibility. This Meta-analysis indicates that the TB risk in Europeans with gene T was 45% lower than those with gene G (T vs. G: OR=0.55, 95%CI=0.31-0.98, P=0.042). As for IL-6-174G/C, nine studies containing 1445 cases and 1955 controls were involved. The TB risk in Americans with gene G was 1.65 times higher than those with gene C (G vs. C: OR=1.65, 95%CI=1.28-2.13, P<0.01), and the TB risk in Asians with gene G was 1.4 times higher than those with gene C (G vs. C: OR=1.40, 95%CI=1.13-1.72, P=0.002).Conclusion This Meta-analysis indicates that the IL-2-330T/G polymorphism is associated with decrease in TB risk in Europeans, and IL-6-174G/C polymorphism is associated with increase in TB risk in Americans and Asians.

Key words: Tuberculosis, Interleukin-2, Interleukin-6, Polymorphism,single nucleotide, Disease susceptibility, Meta-analysis

Yan-lin LI,Liang LI,Xiu-fang TANG,Xiu-juan WU. Association of IL-2-330T/G and IL-6-174G/C polymorphisms with tuberculosis susceptibility: a Meta-analysis[J]. Chinese Journal of Antituberculosis, 2018, 40(3): 263-268. doi: 10.3969/j.issn.1000-6621.2018.03.010

Figures/Tables 7

References 23

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地区	等位基因模型 (T对G)		纯合子模型 (TT对GG)		杂合子模型 (TG对GG)		显性模型 (TT+TG对GG)		隐性模型 (TT对TG+GG)
地区	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值
总体	0.75 (0.59~0.95)	0.019	0.57 (0.32~1.02)	0.056	0.97 (0.56~1.67)	0.902	0.77 (0.47~1.25)	0.290	0.62 (0.42~0.93)	0.020
亚洲	0.81 (0.60~1.10)	0.174	0.66 (0.28~1.54)	0.331	0.83 (0.32~2.16)	0.702	0.78 (0.32~1.91)	0.581	0.74 (0.50~1.10)	0.134
欧洲	0.55 (0.31~0.98)	0.042	0.36 (0.13~1.00)	0.049	1.08 (0.60~1.98)	0.791	0.66 (0.38~1.13)	0.127	0.36 (0.12~1.05)	0.061
美洲	1.02 (0.74~1.40)	0.927	1.13 (0.56~2.27)	0.728	1.23 (0.61~2.50)	0.566	1.18 (0.60~2.29)	0.634	0.96 (0.63~1.47)	0.857

地区	等位基因模型 (G对C)		纯合子模型 (GG对CC)		杂合子模型 (GC对GG)		显性模型 (GG+GC对CC)		隐性模型 (GG对GC+CC)
地区	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值
总体	1.40 (1.21~1.62)	<0.01	1.98 (1.36~2.87)	<0.01	1.46 (1.00~2.14)	0.049	1.75 (1.22~2.52)	0.002	1.44 (1.21~1.72)	<0.01
亚洲	1.40 (1.13~1.72)	0.002	2.15 (1.17~3.92)	0.013	1.51 (0.83~2.75)	0.179	1.85 (1.03~3.32)	0.040	1.43 (1.12~1.83)	0.005
欧洲	1.09 (0.79~1.50)	0.594	1.25 (0.62~2.52)	0.528	1.23 (0.60~2.53)	0.573	1.25 (0.64~2.46)	0.518	1.06 (0.70~1.61)	0.773
美洲	1.65 (1.28~2.13)	<0.01	2.64 (1.39~5.01)	0.003	1.63 (0.84~3.15)	0.149	2.20 (1.18~4.12)	0.014	1.76 (1.28~2.41)	<0.01