Abstract: ObjectiveTo find out the status of drug resistance (DR) of Mycobacterium tuberculosis and multi drug-resistance tuberculosis (MDR-TB) situation in Linxia, Gannan and Dingxi in Gansu province, and to provide scientific evidence for TB control in minority and poor area. MethodsAccording to the guidelines for Surveillance of Drug Resistance in Tuberculosis (WHO/ IUATLD), all new smear positive cases and new registered retreatment smear positive cases in one year in survey area were the cases for surveillance. A total of 909 isolated strains of Mycobacterium tuberculosis were tested for drug susceptibility by the absolute concentration method. ResultsThe overall drug resistance was 26.0%, the primary drug resistance was 21.0% and the acquired drug resistance was 50.0%; multi-drug resistance was 10.1%, the rates were 7% and 24.1% respectively for primary multi-drug resistance and acquired multi-drug resistance; 70.8% RFP-resistant strains were MDR-TB strains. ConclusionThe incidence of drug resistance of Mycobacterium tuberculosis in minority in Gansu province is high, health administrative department and TB control institute at each level should pay attention to drug resistance.

Key words: Mycobacterium tuberculosis, drug resistance,bacterial, Gansu province