Abstract: Objectives To evaluate the magnitude and pattern of drug resistant tuberculosis in Xinjiang,and to assess TB control performance in the region. Methods Thirty clusters were randomly selected with cluster sampling method.According to case enroll criteria,all the new smear positive cases and retreated smear positive cases during the survey period were involved and their sputum were collected for culture. Results Drug susceptibility testing against INH,RFP,SM and EMB were performed in 1083 cases.The overall drug resistance,drug resistance among new cases and retreated smear positive cases were 26.4%,25.9% and 30.7%,and the multi-drug resistance rate was 4.6%. Conclusions The prevalence of drug resistant tuberculosis is rather high in Xinjiang,and the quality of TB control performance need to be strengthened.

Key words: tuberculosis, drug resistance, surveillance