Abstract:

Diagnostic methods for tuberculosis, particularly those based on pathogen detection, are extensively employed in clinical laboratories. However, these methods often fail to meet the clinical demands for rapid and accurate diagnosis, primarily due to the challenge posed by the low bacterial load in biological samples. The integration of enrichment technologies for Mycobacterium tuberculosis detection holds significant promise in enhancing both the sensitivity and accuracy of tuberculosis diagnostic assays, thereby improving clinical outcomes. In this review, we examine the current research on Mycobacterium tuberculosis enrichment technologies, aiming to provide valuable insights for the development and application of novel enrichment methods. We anticipate the emergence of more efficient techniques that will significantly enhance the sensitivity of tuberculosis diagnostic assays. This advancement is crucial for achieving early detection, diagnosis, and treatment, ultimately reducing tuberculosis transmission and mitigating adverse prognoses.

Key words: Mycobacterium tuberculosis, Bacteriological techniques, Review