Email Alert | RSS

Chinese Journal of Antituberculosis ›› 2024, Vol. 46 ›› Issue (8): 976-981.doi: 10.19982/j.issn.1000-6621.20240111

• Review Articles • Previous Articles     Next Articles

Advances in the application of metagenomic sequencing for tuberculosis prevention and control

Wang Yiting1, Meng Xiangli2, Fu Yin1, Cao Xiaolong3, Zheng Huiwen4, He Wencong5, Song Zexuan3, Zhao Yanlin3()   

  1. 1Institution for Immunization and Prevention,Beijing Center for Disease Prevention and Control, Beijing 100013,China
    2Ningbo International Travel Healthcare Center, Ningbo Customs District, Ningbo 315012,China
    3National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing 102206,China
    4Laboratory of Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Center for Children’s Health, Beijing 100045,China
    5Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730,China
  • Received:2024-03-27 Online:2024-08-10 Published:2024-08-01
  • Contact: Zhao Yanlin E-mail:zhaoyl@chinacdc.cn
  • Supported by:
    National Key Research and Development Program of China(2022YFC2305200);Ningbo Natural Science Foundation(2018A610238);Beijing Natural Science Foundation(7224328)

Abstract:

Effective diagnosis is crucial for controlling tuberculosis outbreaks, yet conventional diagnostic approaches lack sensitivity and are notably time-consuming, failing to satisfy the demands for high-efficiency clinical diagnostics. With the advent of advanced sequencing technologies and bioinformatics, metagenomic sequencing has increasingly been recognized for its utility in the diagnosis of a broad spectrum of infectious diseases. This study explores the application of metagenomic sequencing in the management and diagnosis of tuberculosis, emphasizing its transformative potential for future enhancements in the prevention of tuberculosis.

Key words: Tuberculosis, Molecular diagnostic techniques, Review

CLC Number: