Abstract:

Objective: Epidemiological characteristics and therapeutic prognosis of patients suffering from pulmonary tuberculosis combined with diabetes mellitus (PTB-DM) registered in Guangzhou City from 2014 to 2023 were analyzed to provide evidence for formulating measures to prevent and treat PTB-DM. Methods: Basic information of PTB-DM patients registered in Guangzhou from 2014 to 2023 were collected from the “TB Information Management System” of the “China Disease Control and Prevention Information System”. Descriptive epidemiological method was used to analyze the epidemiological characteristics and treatment outcomes of PTB-DM patients and patients with PTB alone. Non-conditional logistic regression model was used to analyze the influencing factors of PTB-DM. Results: All of 2468 PTB-DM cases were registered in Guangzhou from 2014 to 2023 with an average annual registration rate of 1.44/100000, accounting for 2.79% (2468/88307) of all PTB patients, and the proportion showed an overall upward trend ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=131.002, P<0.01). Non-conditional logistic regression analysis showed that compared with PTB patients who were younger, female, teachers/medical personnel/cadres, taking primary treatment, detected from health examination, not delayed in care seeking, and etiologically negative, patients who were older, male, doing housework/unemployed/farmer/herdsmen/fishermen/workers, taking retreatment, detected from referral or tracking, delayed in care seeking, and etiologically positive were more likely to have diabetes mellitus, the odds ratios were 1.436, 1.508, 1.386, 1.781, 1.442, 1.178, 2.050, 3.796, 3.688, 1.670 and 3.064, respectively. Among 83490 tuberculosis patients who had treatment outcomes recorded, the overall treatment success rate was 93.56% (78114/83490), while the success treatment rate was 89.52% (1990/2223) in PTB-DM patients, lower than 93.67% (76124/81267) in PTB patients without DM (χ²=61.942, P<0.05). Conclusion: PTB-DM patients in Guangzhou were mainly middle-aged and elderly adults, male, doing housework or unemployed. They had the characteristics of high retreatment rate, high etiologically positive rate, high drug resistance rate, high patient delay rate, low active detection rate and low treatment success rate. Two-way screening for PTB-DM should be strengthened to achieve early detection and treatment.

Key words: Tuberculosis, pulmonary, Diabetes mellitus, Comorbidity, Epidemiological characteristics, Factor analysis,statistical