Research progress on macrophage polarization and Mycobacterium tuberculosis infection

doi:10.19982/j.issn.1000-6621.20230265

Abstract

Abstract:

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB), which seriously endangers human health, and the emergence of drug-resistant MTB greatly exacerbates the difficulty of treatments. As an essential factor against MTB, macrophage polarizes into two subpopulations including M1 and M2 types once infected, which exhibit distinguish impacts during host infection. Macrophage polarization is tightly related to the occurrence, progression, and prognosis of tuberculosis diseases. In this review, the authors summarized the dynamic balance of polarization between M1 and M2 macrophages and polarization-related pathways during MTB infection, which might provide some perspectives for vaccine development, prevention, and treatment of tuberculosis diseases.

Key words: Mycobacterium tuberculosis, Polarization, Macrophage, Review literature as topic

CLC Number:

R152
R183.3

Wu Xianjin, Huang Haiyong, Xiao Leyao, Xu Junfa. Research progress on macrophage polarization and Mycobacterium tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2023, 45(12): 1198-1204. doi: 10.19982/j.issn.1000-6621.20230265

Figures/Tables 1

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