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Chinese Journal of Antituberculosis ›› 2022, Vol. 44 ›› Issue (6): 595-599.doi: 10.19982/j.issn.1000-6621.20210709

• Original Articles • Previous Articles     Next Articles

Influence of malnutrition on positive rate of interferon gamma release assay (IGRA) in patients with tuberculosis

LA Ba, ZHANG Meng-meng, WANG Ming-gui, HE Jian-qing()   

  1. Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
  • Received:2021-12-17 Online:2022-06-10 Published:2022-06-01
  • Contact: HE Jian-qing E-mail:jianqing_he@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China Grants(81870015)

Abstract:

Objective: To investigate whether malnutrition affects the positive rate of γ-interferon release assay (IGRA) in patients with tuberculosis. Methods: From January 2015 to November 2018, 443 patients with tuberculosis who were admitted to the Department of Respiratory and Critical Care Medicine, West China Hospital were included by reviewing electronic medical record. According to body mass index (BMI), they were divided into malnutrition group (BMI <18.5; 136) and no-malnutrition group (BMI ≥18.5; 307). Enzyme linked immunosorbent assay was used to measure the concentration of interferon-γ in fresh heparinized whole blood stimulated by tuberculosis specific antigen in vitro. The positive rate of IGRA in the two groups was compared. Results: A total of 443 patients, the positive rate of IGRA was 76.47% (104/136) in the malnourished group and 78.18% (240/307) in the no-malnutrition group, there was no significant difference between the two groups (χ2=0.158,P=0.712). Among the bacterium-confirmed tuberculosis patients, the positive rate of IGRA was 75.61% (31/41) in the malnutrition group and 80.65% (50/62) in the no-malnutrition group, there was no significant difference between the two groups (χ2=0.373,P=0.542). Conclusion: Malnutrition does not affect the positive rate of IGRA in patients with tuberculosis.

Key words: Tuberculosis, Interferon-gamma, Immunologic tests, Nutritional assessment, Comparative study

CLC Number: