The role and application of cytokines interleukin-7 and interleukin-15 in tuberculosis infection

doi:10.3969/j.issn.1000-6621.2018.04.015

Abstract

Abstract:

Interleukin (IL)-7 and IL-15, the members of IL-2 family, have attracted much attention because of their important roles in regulating T cell differentiation and proliferation and information and maintenance of immune memory recently. Both IL-7 and IL-15 have a heterotripolymer structure similar to that of IL-2, are involved in the Janus kinase (a class of non-transmembrane tyrosine kinases)/signal transducer and activator of transcription (JAK/STAT) signaling pathway, and play a role in regulating the balance of the helper T lymphocyte (Th) 1/2 cytokines. Compared with IL-2, IL-7 and IL-15 can sustainably play a role in maintaining anti-tuberculosis (TB) function of T lymphocytes, and differentially diagnose TB due to their dynamic profile during infection. Furthermore,IL-7 and IL-15 can enhance secondary immune responses and play an important role in the development of prophylactic or therapeutic anti-TB vaccines.

Key words: Interleukin-7, Interleukin-15, Immunity,cellular, Tuberculosis, Immune system processes, Review

Bing-ye LIU,De-cheng WANG,Xiao-yong FAN. The role and application of cytokines interleukin-7 and interleukin-15 in tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2018, 40(4): 425-428. doi: 10.3969/j.issn.1000-6621.2018.04.015

Figures/Tables 1

References 20

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名称	结构与大小	主要合成场所	受体	功能
IL-2	相对分子质量15500,133个氨基酸,四螺旋结构	活化的T细胞	IL-2Rα和IL-2Rβ、γ被活化的T/B细胞共表达	自然杀伤细胞(NK细胞)、T细胞与B细胞的增殖和分化,消除自身反应性T细胞,介导活化诱导的细胞死亡作用和维护调节性T细胞
IL-7	相对分子质量25000,152个氨基酸,四螺旋结构	骨髓基质细胞和胸腺细胞	由IL-7Rα和IL-7Rγ组成,表达于大多数静息T细胞	促进前B细胞增殖;影响记忆性T细胞的存活;参与和影响调节性T细胞增殖
IL-15	相对分子质量14000~15000,114个氨基酸,四螺旋结构	树突状细胞、巨噬细胞和肌肉组织等	单核巨噬细胞和树突状细胞表面的IL-15Rα将IL-15转运到自然杀伤细胞、CD8⁺ T细胞,表达IL-15Rβ/γ	参与自然杀伤细胞、T细胞及B细胞的增殖和分化,维持CD8⁺ 记忆性T细胞