Abstract: Objective To explore the effect of application of the clinical nursing pathway on health education in patients with MDR-TB.  Methods One hundred and five patients with MDR-TB were assigned to clinical pathway group(55 cases) and control group(50 cases). The clinical pathway group included 35 male and 20 female, the average age was（51±13.8）years old. The control group included 31 male and 19 female,the average age was（52±11.9）years old. Patients in clinical pathway group received health education with clinical nursing pathway and those in control group received health education with conventional care program. Change of life behavior, nursing satisfaction and compliance of taking anti-tuberculosis drugs were compared between the clinical pathway group and the control group. Data were analyzed with chi-square test. P-value＜0.05 was considered to be statistically significant. Results In terms of the score of treatment compliance, in the clinical pathway group, 50 cases got 4 scores, 5 cases got 3 scores, no case got 2 scores, no case got 1 score. In contrast, in the control group, 25 cases got 4 scores, 10 cases got 3 scores, 5 cases got 2 scores, 10 cases got 1 score. In terms of the cognitive behavior change, in the clinical pathway group, 40 cases had general understanding, 12 cases had partial understanding and 3 cases could not understand. In the control group, 19 cases had general understanding, 18 cases had partial understanding and 13 cases could not understand. In terms of the nursing satisfaction, in the clinical pathway group, 47 cases were satisfied with the health education, 5 cases felt partly satisfaction, 3 cases felt basic satisfaction and no case felt unsatisfactory. In the control group, 30 cases were satisfied with the health education, 8 cases felt partly satisfaction, 7 cases felt basic satisfaction and 5 cases felt unsatisfactory. Three above assessment indicators between the clinical pathway group and the control were significantly different. The chi-square value were 26.52，8.56 and 6.95 respectively. The indicator in the clinical pathway group was higher than those in the control(all P<0.01）. Conclusion Management of clinical pathway can improves treatment compliance,nursing care satisfaction and cognitive behavior change in patients with MDR-TB.

Key words: Tuberculosis, pulmonary/nursing, Tuberculosis, multidrug-resistant/nursing, Health education, Evaluation studies