Abstract: Objective To obtain the data on drug resistances(DR) of Mycobacterium tuberculosis complexes(MTBC) strains isolated from the patients of Beijing in 2004.Methods All new registered bacterium-positive patients were selected in 2004.One percent proportion method was used for drug susceptibility testing of isoniazid,rifampicin,streptomycin and ethambutol,according to the Guidelines for surveillance of drug resistance in tuberculosis of WHO/lUATLD. Results 1197 TB cases were enrolled.The total DR rate was 20.1% and total multi-drug resistance(MDR) was 3.5%.The initial DR rate was 17.9% and initial MDR rate was 2.3%.The acquired DR rate was 35.1% and acquired MDR rate was 11.7%.Conclusions All types of DR rates of MTBC strains isolated from the patients of Beijing were lower than the reports of other provinces of China,especially in the initial MDR rate.There are higher relativity between acquired drug resistance and acquired MDR resistance.

Key words: Tuberculosis, Drug resistance,Bacterid, WHO