The clinical observation on adjunctive immunotherapy with recombinant human IL-2 in adults with retreatment pulmonary tuberculosis

Abstract

Abstract: Objective To study and evaluate the clinical effects of adjunctive immunotherapy with recombinant human IL-2 in adults with retreatment pulmonary tuberculosis. MethodForty-three sputum smear positive retreatment TB patients were enrolled into this study. There are 22 cases in intervention group and 21 cases in control group. The chemotherapeutic regime which was 2HL2AK(E)Z(TH)V+IL-2/1HL2(TH)V+IL-2/5HL2V in intervention group and 2HL2AK(E)Z(TH)V/1H L2(TH)/5HL2V in control group. ResultForty patients completed the treatment course, their outcome were evaluated. Among of them, 20 patients from intervention group and 20 patients from control group. The sputum smear-conversion, lesion absorbed, cavity shrunk and immune test Results in intervention group were better than that of control group. There were no severe side-effects among patients received IL-2 for treatment. ConclusionThe study suggest that the recombinant IL-2 would be not only a safe biological agent, but also an adjunctive immunotherapy for retreatment pulmonary tuberculosis, which can facilitate smear , lesion absorbed, immunity of patients with pulmonary tuberculosis.

Key words: Pulmonary tuberculosis, IL-2, Clinical study

Zhang Hongmei, Wu Weihua, Han Zhirong, et al.. The clinical observation on adjunctive immunotherapy with recombinant human IL-2 in adults with retreatment pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2005, 27(4): 219-223.

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