Abstract: Objective To determine the bacterial strains’ distribution of tuberculosis accompanied with lower respiratory infection and select sensitive drugs. Method The isolated strains from 111 cases with tuberculosis accompanied with lower respiratory infection in our hospital during 2002 and 1239 contemporary cases in another 10 hospitals in Tianjin were reviewed. We focused on the distribution of their bacterial strains and the Results of Antimicrobiol Susceptibility test on Klebsiella pneumoniae, Pseudomonas aeruginosa,Acinetobader baumannii,Serratia liquefaciens. All data were analyzed by SPSS software. Result There were 28 kinds of pathogenetic bacterial infection.The top 8 among these were Klebsiella pneumoniae(19.8%), Pseudomonas aeruginosa(13.5%), Acinetobader baumannii (9.9%),Monilia albicans (7.2%),Serratia liquefaciens (5.4%),Stap.aureus (5.4%),E.coli (4.5%) and E.cloacae (2.7%) respectively. Conclusions The four pathogenic bacterium with top high infection rates were all highly sensitive to Amikacin and Ciprofloxacin.Furthermore, Amikacin and Ciprofloxacin were both effective on tubercle bacillus and have been served as the second-line drug for antituberculosis. Therefore,they should be the first choice of the antibiotics for tuberculosis (especially for previously treated pulmonary tuberculosis ) accompanied with lower respiratory infection.

Key words: tuberculosis, lower respiratory infection, pathogenetic bacterial, Antimicrobiol Susceptibility