Abstract: Objective To investigate the mechanism of captopril's protecting the kidney of diabetic patients with pulm.Tuberculosis(PTB)by aminoglycoside(AG).Methods 85 diabetic cases with PTB were divided into treating group(44 cases,group A) and control group(41 cases,group B),AG were used in both A and B group,Patients in group A took captopril during treatment.Urinary micro-albumin,β 2-m,serum creatinine and creatinine clearance were measured before and after treatment.Results Urinary β 2-m in group A decreased significantly after tretment than that before treatment(P<0.05),the others had no significant change.But urinary microalbumin and β 2-m in Group B increased significantly(P<0.01 and P<0.05),Conclusion Captopril can reduce the amount of urinary albumin and protect the kidney function on cases of diabetics with PTB.

Key words: Captopril, Aminoglycoside, Tuberculosis, pulmonary