Chinese Journal of Antituberculosis ›› 2019, Vol. 41 ›› Issue (12): 1246-1251.doi: 10.3969/j.issn.1000-6621.2019.12.003
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Di WU,You-fei LIN,Xiao-hong CHEN,Jian-shan SHEN,Xiao-you CHEN()
Received:
2019-09-25
Online:
2019-12-10
Published:
2019-12-13
Contact:
Xiao-you CHEN
E-mail:chenxy1998@hotmail.com
Di WU,You-fei LIN,Xiao-hong CHEN,Jian-shan SHEN,Xiao-you CHEN. Study on the diagnostic value of IL-27 and ADA alone and in combination in the tuberculous pleurisy[J]. Chinese Journal of Antituberculosis, 2019, 41(12): 1246-1251. doi: 10.3969/j.issn.1000-6621.2019.12.003
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单独或联合检测 胸腔积液 | 结核组 (61例) | 恶性组 (40例) | 敏感度 (%) | 特异度 (%) | 准确度 (%) | 阳性预测值 (%) | 阴性预测值 (%) | Kappa值 |
---|---|---|---|---|---|---|---|---|
IL-27 | 85.25 | 82.50 | 84.16 | 88.14 | 78.57 | 0.672 | ||
阳性 | 52 | 7 | ||||||
阴性 | 9 | 33 | ||||||
ADA | 93.44 | 87.50 | 91.09 | 91.94 | 89.74 | 0.813 | ||
阳性 | 57 | 5 | ||||||
阴性 | 4 | 35 | ||||||
IL-27+ADA(并联试验) | 96.72 | 75.00 | 88.12 | 85.51 | 93.75 | 0.743 | ||
阳性 | 59 | 10 | ||||||
阴性 | 2 | 30 | ||||||
IL-27+ADA(串联试验) | 81.97 | 95.00 | 87.13 | 96.15 | 77.55 | 0.753 | ||
阳性 | 50 | 2 | ||||||
阴性 | 11 | 38 |
[1] | Seibert AF, Haynes J Jr, Middleton R , et al. Tuberculosis pleural effusion.Twenty-year experience. Chest, 1991,99(4):883-886. |
[2] | Sales RK, Vargas FS, Capelozzi VL , et al. Predictive models for diagnosis of pleural effusions secondary to tuberculosis or cancer. Respirology, 2009,14(8):1128-1133. |
[3] | Kelam MA, Ganie FA, Shah BA , et al. The diagnostic efficacy of adenosine deaminase in tubercular effusion. Oman Med J, 2013,28(6):417-421. |
[4] | Yang WB, Liang QL, Ye ZJ , et al. Cell Origins and Diagnostic Accuracy of Interleukin 27 in Pleural Effusions. PLoS One, 2012,7(7):e40450. |
[5] | 陈秋悦, 顾刚, 龙燕华 , 等. 胸腔积液行γ-干扰素诱导蛋白10及腺苷脱氨酶检测的诊断价值. 中国防痨杂志, 2017,39(11):1169-1174. |
[6] | 中华人民共和国国家卫生和计划生育委员会. WS 288—2017 肺结核诊断. 2017-11-09. |
[7] | Korczynski P, Klimiuk J, Safianowska A , et al. Impact of age on the diagnostic yield of four different biomarkers of tuberculous pleural effusion. Tuberculosis, 2019,114:24-29. |
[8] | Light RW . Pleural diseases. 6th ed. Philadelphia: Williams & Wilkins, 2013. |
[9] | Wang XJ, Yang Y, Wang Z , et al. Efficacy and safety of diagnostic thoracoscopy in undiagnosed pleural effusions. Respiration, 2015,90(3):251-255. |
[10] | Light RW, Lee YCG. Textbook of Pleural Diseases,2nd Edition. Boca Raton: CRC Press, 2008. |
[11] | Sales RK, Vargas FS, Capelozzi VL , et al. Predictive models for diagnosis of pleural effusions secondary to tuberculosis or cancer. Respirology, 2009,14(8):1128-1133. |
[12] |
徐健, 刘春芳, 韩雪 , 等. 可弯曲内科胸腔镜术对未明原因胸腔积液的诊断价值及随访的临床意义. 中华结核和呼吸杂志, 2014,37(1):64-66.
doi: 10.3760/cma.j.issn.1001-0939.2014.01.022 URL |
[13] | 谢强, 魏淑芳, 陈群 , 等. 可弯曲电子内科胸腔镜在结核性胸膜炎诊断中的应用. 中国防痨杂志, 2010,32(4):221-223. |
[14] | O’Dwyer MJ, Mankan AK, White M , et al. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expressions. Intensive Care Med, 2008,34(4):683-691. |
[15] | Yoshida H, Hamano S, Senaldi G , et al. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity, 2001,15(4):569-578. |
[16] | Robinson CM, O’Dee D, Hamilton T , et al. Cytokines involved in interferon-gamma production by human macrophages. J Innate Immun, 2010,2(1):56-65. |
[17] | Robinson CM, Nau GJ . Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis. J Infect Dis, 2008,198(3):359-366. |
[18] | Liu H, Rohowskykochan C . Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1. J Interferon Cytokine Res, 2011,31(5):459-469. |
[19] | Hölscher C, Hölscher A, Rückerl D , et al. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol, 2005,174(6):3534-3544. |
[20] | Yang HB, Shi HZ . T lymphocytes in pleural effusion. Chin Med J (Engl), 2008,121(7):579-580. |
[21] | Xia H, Ye ZJ, Zhou Q , et al. IL-27 and IL-27-producing CD4 + T cells in human tuberculous pleural effusion . Tuberculosis, 2014,94(6):579-588. |
[22] | Skouras VS, Magkouta SF, Psallidas I , et al. Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. Infect Dis, 2015,47(7):477-483. |
[23] | 孙美玲, 闫迪, 姜淑娟 , 等. 白细胞介素-27对结核性胸腔积液的诊断价值. 中华医学杂志, 2014,94(34):2641-2644. |
[24] | Wang W, Zhou Q, Zhai K , et al. Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. Thorax, 2018,73(3):240-247. |
[25] | Valdés L, San José E, Ferreiro L , et al. Interleukin 27 could be useful in the diagnosis of tuberculous pleural effusions. Respir Care, 2014,59(3):399-406. |
[26] | Piras MA, Gakis C, Budreni M , et al. Adenosine deaminase activity in pleural effusions:an aid to differential diagnosis. British Med J, 1978,2(6154):1751-1752. |
[27] | Liang QL, Shi HZ, Wang K , et al. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis. Respir Med, 2008,102(5):744-754. |
[28] | 唐静, 张先明, 万方 , 等. 联合检测三种细胞因子对结核性和恶性胸腔积液的鉴别诊断价值. 中国防痨杂志, 2017,39(1):76-81. |
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