Abstract:

Objective To investigate the adverse effects of linezolid treated MDR-TB and to provide the opinion for rational drug use.Methods Fourty seven MDR-TB patients hospitaled in the Department of Tuberculosis, Guangzhou Chest Hospital from October 1, 2014 to March 20, 2017 treated by regiman including linezolid were enrolled and linezolid-related adverse drug reaction (ADR) were analyzed.Results The median time of treatment of linezolid in 47 patients was 150 (30-730)d, and 37 cases (78.7%) had 61 cases of ADR,which mainly involving the nervous system, digestive system, blood system and skin. The adverse reactions associated with linezolid were shown as follows: 24 cases of peripheral neuritis (51.1%, 24/47), nausea in 15 cases (31.9%, 15/47), decreased visual acuity in 11 cases (23.4%, 11/47), 3 cases of headache (6.4%, 3/47), as well as insomnia, dizziness, skin rash, and bone marrow suppression were found in each 2 cases (4.3%, 2/47). Most patients had peripheral neuritis (45.9%, 17/37) and nausea (29.7%, 11/37) within 0-6months of medication. More patients had a decrease in visual acuity within 0-8months (27.0%, 10/37). The number of patients with peripheral neuritis, nausea and hypoacuity gradually decreased with the prolongation of the use of drug. Patients with ADR can take symptomatic treatment (47 cases), dose reduction (11 cases), suspend medication (3 cases), and drug withdrawal (11 cases). Among them, 5 cases of peripheral neuritis, 4 cases of visual deterioration, 1 case of bone marrow suppression and 1 cases of nausea stopped taking medication in 37 patients with ADR, 22 cases (59.5%) were improved, 14 cases (37.8%) were not improved, 1 cases (2.7%) was aggravated.Conclusion Linezolid has a higher rate of ADR during the long course of treatment.But it can be used safely when ADR was treated in time.

Key words: Oxazolidinones, Tuberculosis, multidrug-resistant, Hypersensitivity, Treatment outcome, Linezolid