胸腔置管联合透明质酸钠防治结核性胸膜炎胸膜肥厚：成本效果分析

摘要/Abstract

摘要： 目的探索防治结核性胸膜炎胸膜肥厚成本低、效果好的治疗方法。方法64例中至大量游离结核性胸腔积液患者随机分为治疗组和对照组。治疗组胸腔置管完全引流积液后注入透明质酸钠，对照组常规胸穿抽液。统计治疗3个月后2组花费的成本，进行成本效果分析及敏感度分析。结果59例患者参与最后结果分析。治疗3个月后治疗组、对照组胸膜肥厚发生率是6.7%、31.0%（有效率分别是：93.3%、69.0%）（P＜0.05）；成本效果比（C/E）是35.19，47.53，敏感度分析显示C/E 35.63，49.00。结论胸腔置管联合透明质酸钠防治结核性胸膜炎胸膜肥厚是成本低、效果好的方法。

关键词: 结核, 胸膜/并发症, 结核, 胸膜/经济学, 胸膜疾病, 引流术, 透明质酸, 成本及成本分析

Abstract: ObjectiveTo explore the method of lower cost and better results.to prevent pleural thickening(PT) of tuberculous pleurisy. MethodsSixty-four patients with middle to large plerural effusions were randomly assigned to a treatment group and a control group. Patients in treatment group given with sodium hyaluronate via central venous catheter into the thoracic cavity after pleural effusion was drainaged completely，while patients in control group received routine thoracentesis. We calculated the cost after 3 months in two groups respectively and analyzed the cost-effectiveness and sensitivity. ResultsFifty-nine patients were available for final analysis. The incidence rate of PT at 3rd month were 6.7% in treatment group and 31.0% in control group（the effective rate: 93.3% vs. 69.0%,respectively）with statistically significant difference（P＜0.05）；The cost/effective rate were 35.2 in the treatment group and 47.5 in the control group. Sensitivity analysis showed 35.6 in the treatment group and 49.00 in the control group. ConclusionsIntrathoracic cannula combining with administration of sodium hyaluronate is a method of lower cost and better Results to prevent pleural thickening of tuberculous pleurisy.

Key words: Tuberculosis,pleural/complications, Tuberculosis,pleural/economics, Pleural diseases, Drainage, Hyaluronic acid, Costs and cost analysis

周爱莲,孙俊生,何建猷. 胸腔置管联合透明质酸钠防治结核性胸膜炎胸膜肥厚：成本效果分析[J]. 中国防痨杂志, 2009, 31(8): 487-490.

Zhou Ailian¹, Sun Junsheng², He Jianyou³. Intrathoracic cannula combining with sodium hyaluronate to prevent pleural thickening of tuberculous pleurisy: cost/effective analysis[J]. Chinese Journal of Antituberculosis, 2009, 31(8): 487-490.

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