肺结核患者CD4、CD8淋巴细胞变化分析

中国防痨杂志 ›› 2005, Vol. 27 ›› Issue (2): 111-112.

肺结核患者CD4、CD8淋巴细胞变化分析

忻小和；钱五四；

浙江省南湖医院安吉 313310；

出版日期:2005-02-10 发布日期:2005-11-03

Analysis on the change of CD4 and CD8 lymphocytes in pulmonary tuberculosis patients

Xin Xiaohe,Qian Wusi.

Zhejiang Nanhu Hospital ,Anji 313310 China

Online:2005-02-10 Published:2005-11-03

摘要/Abstract

摘要： 目的　观察肺结核患者CD4、CD8淋巴细胞变化,探讨其免疫状态的改变及其意义。方法用流式细胞仪测定31例成人肺结核及12例对照组的CD4、CD8计数值,对测定结果进行统计学分析。结果病人组CD4值明显下降,CD8值无明显变化,CD4下降幅度与病情严重程度、排菌状态无明显关联。结论成人肺结核患者存在以CD4T淋巴细胞下降为突出表现的细胞免疫受损,但其对病情发生、发展无独立的影响作用。

关键词: 结核,肺, CD4细胞, CD8细胞

Abstract: Objective To observe the change of CD4 and CD8 lymphocytes in pulmonary tuberculosis patients and to explore the trend and significance of their immune function Methods Determine the CD4 and CD8 values in 31 adult pulmonary tuberculosis patients and 12 control cases with flow cytometry. And then make a statistical analysis based on the determining Results .Results The CD4 values of the patients declined obviously, the CD8 values had no obvious difference . There was no obvious relationship between the decline extent of CD4 values and the patients’ illness condition, the condition of the discharge of bacteria. Conclusion Damage of cellular immune function existed in the adult pulmonary tuberculosis patients, which prominently manifested in the form of the decline of the CD4T lymphocytes , but it had no absolute effective impact on the occurrence and development of illness.

Key words: Tuberculosis, pulmonary, CD4 cell, CD8 cell

忻小和,钱五四,. 肺结核患者CD4、CD8淋巴细胞变化分析[J]. 中国防痨杂志, 2005, 27(2): 111-112.

Xin Xiaohe,Qian Wusi.. Analysis on the change of CD4 and CD8 lymphocytes in pulmonary tuberculosis patients[J]. Chinese Journal of Antituberculosis, 2005, 27(2): 111-112.