Table of Content

10 February 2004, Volume 26 Issue 2

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A bibliometric examination of the Journal of the Chinese Antituberculosis Association (1991-2002)

Yao Hongyan¹,Shi Lvyuan.

. 2004, 26(2):  65-68. 

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Objective To study the quality of the Journal of the Chinese Antituberculosis Association.Methods 12 volumes of the Journal of the Chinese Antituberculosis Association from 1991 to 2002 were evaluated by bibliometric parameters.Results 778 articles published in 51 issues covered 12 volumes of the Journal of the Chinese Antituberculosis Association were evaluated. The information quantity and the authors of this journal kept increasing trend. The journal had some characters, such as continuity, stability and effectiveness. Conclusion The Journal of the Chinese Antituberculosis Associat ion is evaluated to be a high quality academic journal.

Study on the mechanism of the airway hyperr eponsiveness in patient with pulmonary tuberculosis

Wang Yongxing,Ying Yanfeng.

. 2004, 26(2):  69-71. 

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Objective To study the mechanism of the bro nchial hyperresponsiveness (BHR) in the active pulmonary tuberculosis patients.Methods 75 pulmonary tuberculosis cases and the normal persons in the control group were tested by the pulmonary function,T cell subclasses and histamine provocation test.Results The histamine provocation test positive rate were 16.0%,there were not a significant difference between the histamine provocat ion test positive and negative in T cell subclasses in peripheral blood (CD⁺₃70.7%±8.7% and 73.1%±9.1%、CD⁺₄32.1%±6.3% and 35.6%±4.8%、CD⁺₈43.5% ±7.7% and 41.9%±7.4%、CD⁺₄/CD⁺₈0.9%±0.1% and 1.0%±0.1%),but highert han normal in CD⁺₃ and CD⁺₈ (55.5%±6.3% and 25.7%±4.1%) and lower in CD⁺₄/CD⁺₈ (1.5%±0.2%)(P＜0.01).There were a significant difference in PMMF (provocation test positive group:53.6%±5.5%,negative group:67.8%±6.5%)( P＜0.01).Twelve positive subjects in pulmonary tuberculosis had ten cases PMMF<60%,while negative group were 19.1%,there were a significant difference (P＜0.01).The linear correlation showed,when PMMF decreasing,the dose of PD_20FEV1 decreasing,the degree of BHR increasing,pearson correlation coefficient was 0.86,P＜0.01 .Conclusion In the active pulmonary tuberculosis,the small airway narrow play a key role in the mechanism of BHR and there are not a obviousre lative to the cell mediated immunity.

Analysis on effect of World Bank Loaned TB Control Project in Dingxi

Wang Wen,Zhao Chunrong,Wang Xingrun,et al.

. 2004, 26(2):  72-74. 

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Objective To analyze the effects of TB control project in Dingxi.Methods Collect and analyze the project quarterly reports in the period during 1992-2000.Results 53698 cases suspected of TB were received at the TB clinics.The cure rate of new smear posi tive cases and retreatment smear positive cases was 95.5% and 89.0% respectively.Conclusion The world Bank Loaned TB Control Project in Dingxi made a great progress during last nine years.New registration rate of smear positive is 2.8 times as high as that before the project.Indicating that the poor area is able to successfully implement the TB control project under proper fulfilling the technical strategy of program levels.

Analysis on the implementation results of World Bank Loaned TB Control Project in Shijiazhuang

Wang Yuhong,Zhang Yanting,Mi Yilin,et al.

. 2004, 26(2):  75-77. 

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Objective To analyze the implementation Results of World Bank Loaned TB Control Project in Shijiazhang, and provide scientific base for sustainability of TB control.Methods To summarize and analyze the implementation data from 1991 to 2001.Results During 1991 -2001,10?2396 suspects who with TB symptoms made clinical consultation to TB dispensaries.27149 active TB cases have been detected.The notification rate of active TB cases was raised from 21.02/100,000 in 1993 to 39.96/100,000 in 2001.The notification rate of smear positive cases increased from 16.85/100,000 to 29.75/100,000. The cure rate of new smear positive cases reached 98.7%,the cure rate of retreatment smear positive cases was 94.4%. Conclusion Shijiazhuang gets a satisfactory result in TB control project.

Evaluation on tuberculosis control measures in Wuha n 1989-2000

Xie Hong,Zeng Qingzhi,Fang Cuihong,et al.

. 2004, 26(2):  78-80. 

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Objective To improve tuberculosis control measures and accelerate tuberculosis control in Wuhan.Methods To analyze the Results of the latest tuberculosis epidemiological survey and the reported data in Wuhan and to evaluate the effects of World Bank Loaned Tuberculosis Con trol Project from 1989 to 2000 in Wuhan.Results Since the imple mentation of the project,the case rate of smear positive case and concerned cure rate were rise continuously.The highest one were 3411/100000,95.9% respe ctively.But the case detation rate was still lower (28.2%).Conclusion In spite of the improvement of tuberculosis control measures in last 11 years,the eff iciency of tuberculosis control was unremarkable.That was ascribed to the lower case finding rate.In order to accelerate tuberculosis control,tuberculosis control practices should be integrated into primary healthy care network and case finding and other mearsures should be improved.

Research of method for tuberculosis epidemiology survey

Yang Hualin,Wang Lixia,Duanmu Hongjin,et al.

. 2004, 26(2):  81-83. 

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Objective To establish a new method and calculat ing formula for estimation the prevalence of smear positive tuberculosis. Methods To use the parameter of the smear positive tuberculosis patients between patients who with suspect sympotoms and who without suspect sympotoms for establishing the new estimation method.Results (1)The proportions of the smear positive tuberculosis patients who with suspectsy mpotoms and without suspect sympotoms was 75% and 25% respectively in the 4th TB survey. The formula was established by parameter is:R=Sn×(1+1/3)/N,R is preval ence of smear positive tuberculosis; Sn is the number of smear positive tubercul osis patients who with suspect sympotoms detected in a survey that just focus on TB suspects or screening and examination；N is the number of TB suspects examin ed in the survey.(2)The cost of the survey is lower than routine method. Conclusion The new method is a scientific, simple and convenient, low cost. The method and formula can be used for survey of prevalence of sputum smear positive pulmonary tuberculosis.

Study on 4 kinds of methods combination for detecti on of primary smear and culture negative pulmonary tuberculosis

Jiang Xiufeng,Wang Jiaqi,Dong Huifang,et al.

. 2004, 26(2):  84-88. 

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Objective To evaluate the diagnostic value of 4 kinds of Methods combination used for primary smear and culture negative pulmonary tuberculosis.Methods The 4 testing Methods were PCR ELISA exa mination for sputum;TB DNA, MycoDot method for serum LAM IgG,sandwich ELISA method for serum;sIL 2R and PPD 1TU skin test.4 testing Methods were used individ ually and in combination manner respectively to 57 smear and culture positive cases,58 smear and culture negative cases,41 non tuberculosis respiratory patients and 36 healthy people in control group.Results The positive detection rate of single test by PCR ELIS A,LAM IgG,PPD and sIL 2R for sputum TB negative patients was 43.1% ,37.9%,31.0%,50.0% respectively. In combination examination the positive rates increased remarkblely by the number combined from 2 to 4, they were 56.9%,70.7%,84.5% respectively,and the specificity was 92.2% ,88.3%,88.4% ,remain a higher specificity.Conclusion Using the 4 kinds of Methods to diagnose primary smear and culture negative pulmonary tuberculosis patients can increase the positive rates of detection obviously and remain a higher specificity. It is val uable for widely use of combination method in detection of primary smear and cul ture negative tuberculosis patients.

High concentration and large dose perfusion on trea tment of multi-drug resistance pulmonary tuberculosis

Zhang Yaoting,Yan Liu,Zhang Qinhua,et al.

. 2004, 26(2):  89-91. 

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Objective To evaluate the clinical value and safety of high concentration and large dose perfusion on treatment of multi drug res istance pulmonary tuberculosis.Methods Sixty patients with multi drug resistant pulmonary tub erculosis cases were randomly divided into an experiment and control group.The experiment group was treated by perfusion with levofloxacin (0.2%,60～120 mL) and general antituberculosis chemotherapy.The control group was treated by injecting levofloxacin (0.1%,10～20 mL) and general antituberculosis chemotherapy. Results At the end initial phase of treatment,the sputum conversion rate was 96.7%,foci marked absorption rate was 83.3% in the experiment group,all of which were higher than that of the control’s (73.3% and 53.3% respectively, P＜0.05).Sputum conversion time (32.5 d) in the experiment group was shorter than that of the controls (56.5 d)(P＜0.01). Conclusion The efficacy of the high concentration and large dose perfusion is better than the routine injection in the treatment of multi drug resistance pulmonary tuberculosis.The treatment course was shorted.The expense was lower.No complication and obvious adverse reaction were observed.

Study on drug resistance surveillance of tuberculos is in Wulanchabu Meng of Inner Mongolia

Liu Rihong,Ha Si,Wei Jingrong,et al.

. 2004, 26(2):  92-94. 

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Objective To determin the level of initial and acquired drug resistance in Wulanchabu Meng and to evaluate the effect of current TB co ntrol strategies.Methods According to surveillance guidelines, cluster sampling method was applied to select 3 surveillance sites in Inner Mon golia, including Jining, Liangcheng and Huade. In each site, 26 new smear positive TB patients and all retreatment smear positive TB patients during the same period were selected to participate the study. Bacterial type and susceptibility test (proportion method for SM, INH, RFP and EMB) were conducted for all culture positive samples .Results 107 patients with pulmonary TB were enrolled from 3 surveillance sites. 52.3% of them had drug resistance. The initial drug resis tanc e rate was 35.9% and the acquired drug resistance rate was 76.7%. The initial multi drug resistance rate was 7.8% and the acquired multi drug resistance rate was 53.5%.Conclusion Local drug resistance rate is higher than the average level of the whole country. Acquired drug resistance occur much more frequently among people aged from 25 to 34 years old. More attention should be paid to this situation.

The analysis of drug resistance for out-patient pu lmonary tuberculosis between resident and migrant

Lin Yongming,Chen Qiuyang,Liang Qingfu,et al.

. 2004, 26(2):  95-97. 

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Objective To determine the difference of the drug resistance of M.tuberculosis between resident TB cases and migrant TB cases from out patient.Methods Absolute concentration method was used for susceptibility test of 5 antituberculosis drugs.Results There was no significant difference on drug resistance rates of those two grou ps. The mostly cases of initial resistance resisted to one drug, and those of acquired resistance resisted to multi drugs. The rate of drug resistance among migrant TB cases was higher than that of the resident TB cases. Conclusion The rate of drug resistance was high,so we must strengthen surv eillance on antituberculosis drug resistance.

The clinic analysis on the effect of Mycobacterium vaccae vaccine to treatment outcome of new bacteriological positive pulmonary tu berculosis cases

Gao Weihong,Gao Chunrong,Chen Lei.

. 2004, 26(2):  98-100. 

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Objective To evaluate the effect and safety of Mycobacterium vaccae vaccine (M.vaccae vaccine) to treatment outcome of new pulmonary tuberculosis cases.Methods 168 new bacteriological positive pulmonary tuberculosis cases were divided into immunotherapy (A,84 cases)group and control (B,84 cases) group randomly.The cases in two groups were treated by the same chemotherapy regimen of 2HRZE/4HR.The group A were treated immunotherapy with M.vaccae vaccine for 2 months.There was no immonotherapy with M.vac cae in group B.Results The sputum smear negative conversion rates in group A 1,2 and 6 months after treatment were 36.9%, 79.8% and 97.6% respec tively;those in group B were 19.0%,53.8% and 96.4% respectively.The sputum culture-negative conversion rates in group A the end of 1,2 and 6 months treatment were 47.6%,85.7% and 98.8% respectively;those in group B were 17.9% ,67.9% and 97.6% respectively.The sputum negative conversion rates of group A were signi ficantly higher than those of group B after 1 and 2 months treatment(P＜0.01 ).But there were no statistically significant differences between the two groups at the end of 6 months after treatment (P＞0.05).Compared with group B,the effect on improving of X ray manifestation in group A were better (P＜0.01).The side effects of M.vaccae vaccine were rare and slight.The bacterio logical relapse rates in group A,B were 1.3%,2.6% respectively(P＞0.05). Conclusion M.vaccae vaccine is helpful on speeding negative conversion,improving of X ray monifestation for new bacteriological positive pul monary tuberculosis.

The evaluation on four reports of tuberculosis drug resistance surveillance

Deng Yunfeng,Sun Shuli,Yu Chunbao,et al.

. 2004, 26(2):  101-103. 

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Objective To evaluate and compare 4 reports of tuberculosis drug resistance surveillance of He’nan,Shandong,Zhejiang and Guangdong province.Methods According to the guidelines of WHO/IUATLD drug resistance surveillance of tuberculosis project, the items of every report was checked and analyzed.Results There were difference on estimation of sample size,technique indexes which be used in laborat ories, the definitions of primary and acquired drug resistance among four reports.Conclusion Only the standardization of Methods be us ed,the Results will be comparable among participating laboratories. It is impor tant to establish surveillance of drug resistance system in nationwide.

The relation between date to positive of Mycobact erium tuberculosis in sputum culture and outcome of treatment

Xiao Peng,Wu Longzhang,Wang Xiaojie,et al.

. 2004, 26(2):  104-106. 

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Objective To determine the relation between the date to positive (DTP) of Mycobacterium tuberculosis in sputum culture and the treatment outcome of pulmonary tuberculosis treatment.Methods 56 patients suffering from pulmonary tuberculosis were studied with consecutive sputum cultures and clinical follow up for assessment.Results Following initiation of antituberculous therapy 40 patients (group A) had a positive response to treatment, and the DTP of Mycobacterium tuberculosis using MB/BacT tube cultured in Bac T/ALERT 3D increased steadily. The other 16 patients (group B) had persistent ev idence of active disease and the DTP demonstrated little or no increase with tre atment unless an additional therapeutic intervention was implemented (surgery, a dditional administration via bronchoscope timely, or a change in medication). Conclusion The DTP was superior to clinical, radiographic, or conventional bacteriologic evaluation on anticipating treatment outcome. There was a close relation between the DTP and the overall response to treatment for pul monary tuberculosis cases.It would be a good clinical method to predict the trea tment outcome.

Clinical significance of the examination to MTB-L

Wu Fengxia,Li Huiling,Wang Xinjun.

. 2004, 26(2):  107-109. 

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Objective To investigate the clinical significance of the examination to Mycobacterium tuberculosis L type (MTB L). Methods There were 314 specimens from 314 cases with tuberculos is: 312 portions of sputum, 1 portion of prostatic fluid and 1 portion of semen. The specimens were digested, adjusted PH and then centrifugalized for 30 minutes with 3800 turns per minute. Picked the sediments and inoculated them to 92 TB L and common TB culture bases as the control.The following Results were anal ysised:(1) The positive ratio of MTB L and MTB culture in initial and retreatment cases, extra pulmonary cases and cured cases. (2)The relationship between positive rate of sputum MTB L culture and the duration that patients taking clini cal consultation and the onset of illness of initial pulmonary tuberculosis cases. (3)The relationship between positive rate of sputum MTB L culture and the variety and quantity of the first line TB drugs used before of retreatment pu lmonary tuberculosis cases. Results In 314 cases,the co positive rate of MTB and MTB L culture was 42.4%.The single positive rate of MTB L culture was 28.7%.The case with positive result of MTB L culture in initial cases occupied 64.8% of the total positive cases (59/91) and related with the durati on of clinical consultation. There was significant difference of the positive rates between that of cases who taking clinical consultation exceeding one month and less than one month (P＜0.05). In retreatment cases,the cases with positive result of MTB L culture occupied 72.5% in total retreatment positive cases (29/40) and related to the variety and quantity of the first line TB drugs used before. There was significant difference of positive ratio between 4 drugs and 13 drugs used for more than 3 months (P＜0.01). Conclusions There was great clinical significance of the examin ation to MTB L for diagnosing,judging the activity,assesment the treatment effe ction and guiding the clinical treatment, especially to MTB negative cases.It was important for initial and retreatment patients that they should make clinical consultation timely and be treated regularly to reduce the forming of MTB L.