Abstract: Objective To determin the level of initial and acquired drug resistance in Wulanchabu Meng and to evaluate the effect of current TB co ntrol strategies.Methods According to surveillance guidelines, cluster sampling method was applied to select 3 surveillance sites in Inner Mon golia, including Jining, Liangcheng and Huade. In each site, 26 new smear positive TB patients and all retreatment smear positive TB patients during the same period were selected to participate the study. Bacterial type and susceptibility test (proportion method for SM, INH, RFP and EMB) were conducted for all culture positive samples .Results 107 patients with pulmonary TB were enrolled from 3 surveillance sites. 52.3% of them had drug resistance. The initial drug resis tanc e rate was 35.9% and the acquired drug resistance rate was 76.7%. The initial multi drug resistance rate was 7.8% and the acquired multi drug resistance rate was 53.5%.Conclusion Local drug resistance rate is higher than the average level of the whole country. Acquired drug resistance occur much more frequently among people aged from 25 to 34 years old. More attention should be paid to this situation.

Key words: tuberculosis, drug resistance, surveillance