Abstract: Objective To evaluate the clinical value and safety of high concentration and large dose perfusion on treatment of multi drug res istance pulmonary tuberculosis.Methods Sixty patients with multi drug resistant pulmonary tub erculosis cases were randomly divided into an experiment and control group.The experiment group was treated by perfusion with levofloxacin (0.2%,60～120 mL) and general antituberculosis chemotherapy.The control group was treated by injecting levofloxacin (0.1%,10～20 mL) and general antituberculosis chemotherapy. Results At the end initial phase of treatment,the sputum conversion rate was 96.7%,foci marked absorption rate was 83.3% in the experiment group,all of which were higher than that of the control’s (73.3% and 53.3% respectively, P＜0.05).Sputum conversion time (32.5 d) in the experiment group was shorter than that of the controls (56.5 d)(P＜0.01). Conclusion The efficacy of the high concentration and large dose perfusion is better than the routine injection in the treatment of multi drug resistance pulmonary tuberculosis.The treatment course was shorted.The expense was lower.No complication and obvious adverse reaction were observed.

Key words: Tuberculosis,pulmonary, Multidrug resistant, Bronchof iberscope, Catheterization, Perfusion therapy