Abstract: Objective To determine the difference of the drug resistance of M.tuberculosis between resident TB cases and migrant TB cases from out patient.Methods Absolute concentration method was used for susceptibility test of 5 antituberculosis drugs.Results There was no significant difference on drug resistance rates of those two grou ps. The mostly cases of initial resistance resisted to one drug, and those of acquired resistance resisted to multi drugs. The rate of drug resistance among migrant TB cases was higher than that of the resident TB cases. Conclusion The rate of drug resistance was high,so we must strengthen surv eillance on antituberculosis drug resistance.

Key words: Resident population, migrant, Mycobacterium,tuberculosis, Drug resistance