Abstract: Abstract：Objective  To improve the level of diagnosis and treatment in pulmonary cryptococcosis according to summary the clinical characteristics of ten cases with pulmonary cryptococcosis. Methods  Ten patients with primary pulmonary cryptococcosis hospitalized in the Fourth People’ Hosptital of Foshan from 2006 to 2010 were analyzed for clinical data, imaging, laboratory results, pathological feature, diagnostic method and efficacy. Results  (1)Of ten cases, five cases suffered from basic diseases and eight cases presented  with clinical symptoms, such as cough,fever,hemoptysis, and atypical chest imaging. Seven cases were confirmed by percutaneous lung biopsy and three cases by surgical operation.(2)All patients were treated with fluconazole including three patients received surgical operation before taking fluconazole. There were seven patients cured and two patients improved.The course of treatments ranged from six to twelve months.  Conclusion   Primary pulmonary cryptococcosis present with various clinical features and chest imaging.Lung biopsy can contribute to diagnose. Primary pulmonary cryptococcosis can get satisfactory efficacy with fluconazole only.

Key words: Cryptococcosis, Lung diseases,fungal, Biopsy, Fluconazole