Auxiliary diagnostic value of GeneXpert MTB/RIF assay for extrapulmonary tuberculosis of fine needle biopsy tissue eluent

doi:10.3969/j.issn.1000-6621.2018.11.017

Abstract

Abstract:

To evaluate the auxiliary diagnostic value of GeneXpert MTB/RIF (GeneXpert) for detecting extrapulmonary tuberculosis based on fine needle biopsy tissue eluent, a total of 103 patients with extrapulmonary tuberculosis in Wuhan Pulmonary Hospital between January 2016 and December 2017 were enrolled. All of these patients were operated through fine needle puncture and the biopsy tissue eluent were tested by tuberculosis-DNA PCR assay, GeneXpert, tuberculosis solid culture and smear method, respectively. The results showed that the sensitivity of GeneXpert (78.6% (81/103)) was significantly higher than that of tuberculosis solid culture (26.2% (27/103)) and smear method (16.5% (17/103)), and the differences were statistically significant (χ ² values were 56.76 and 79.72, respectively; all P values <0.05). Hence, it is clear that GeneXpert showed a higher diagnostic sensitivity for detecting extrapulmonary tuberculosis based on fine needle biopsy tissue eluent.

Key words: Tuberculosis, Biopsy, fine-needle, Nucleic acid amplification techniques, Evaluation studies

LIU Qi-liang,LEI Mei,SHI Yi-qun,ZHANG Jing. Auxiliary diagnostic value of GeneXpert MTB/RIF assay for extrapulmonary tuberculosis of fine needle biopsy tissue eluent[J]. Chinese Journal of Antituberculosis, 2018, 40(11): 1235-1236. doi: 10.3969/j.issn.1000-6621.2018.11.017

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