Therapeutic effect of Ag85A/B chimeric plasmid DNA vaccine in the mouse model infected by Mycobacterium tuberculosis

Abstract

Abstract: Objective To evaluate the therapeutic effect of Ag85A/B chimeric plasmid DNA vaccine in the mouse model infected by M.tuberculosis to establish a new immunotherapeutic agent against the tuberculosis.Methods 50 female BALB/c mice were infected intravenously via the tail vein with 68000 CFU of M.tuberculosis H37Rv,then randomly divided into 5 groups,and treated as follow at the third day after infection:group A,saline|group B,plasmid vector|group C,rifampin|group D,Mycobacterium phlei F.U.36 injection|group E...

Key words: vaccine, DNA, tuberculosis/therapy

CLC Number:

LIANG Yan, WU Xue-Qiong, LI Zhong-Ming, LI Ning, ZHANG Jun-Xian, YANG You-Rong, BAI Xue-Juan, YU Qi, HOU Ying, LIU Cui-Hua, AN Hui-Ru, SHI Ying-Chang, LIU Yin-Ping, WANG Bo, WANG Lan, LIU Cheng-Long. Therapeutic effect of Ag85A/B chimeric plasmid DNA vaccine in the mouse model infected by Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2010, 32(10): 37-40.

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Therapeutic effect of Ag85A/B chimeric plasmid DNA vaccine in the mouse model infected by Mycobacterium tuberculosis

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