Abstract: ObjectiveTo analyze retrospectively the status of drug resistance of mycobacterium tuberculosis(MTB) isolated from patients hospitalized in Hunan tuberculosis hospital, and to analyze the causes. MethodsWe analyzed the Results of drug susceptibility testing in 591 strains MTB isolated from May 1,2003 to December 31,2007. The drug susceptibility of all isolates were detected by absolute concentration method among 7 drugs，including INH（H）,RFP(R),SM（S）,PAS (P), EMB (E),KM (K),OFLX（O）.ResultsOf 591 isolates，376(63.6%) isolates were resistant to one drug at least. 1(0.2%) isolates was resistant to all seven drugs. 228(38.6%) were MDR isolates. ConclusionsThe situation of drug resistance is very serious. Strategies should be stringently taken to prevent and treat patients with drug-resistance pulmonary tuberculosis.

Key words: tuberculosis, Mycobacterium tuberculosis, microbial sensitivity tests, drug resistence, multiple