The clinical diagnostic value of detection of P-selectin, IL-1α, sFas, sFasL, AM in differentiating tuberculous pleural effusions from malignant pleural effusions

Abstract

Abstract: Objective To evaluate the diagnostic values and clinical significance of detecting P-selectin, IL-1α,soluble Fas,soluble FasL and adrenomedullin(AM)in pleural effusions in different tuberculous pleural effusions and malignant pleural effusions, and compare with CEA. Methods The level of P-selectin,IL-1α, soluble Fas, soluble FasL in tuberculous and malignant pleural effusions were determined by Enzyme-linked immunosorbent assay(ELISA) ,and that of AM and CEA were determined by radioimmunoassay(RIA). Results (1)The level of P-selectin and IL-1a in tuberculous pleural effusions was markedly lower than that in malignant pleural effusions( t= 8.71, P＜0.001) . (2)The level of sFasL and sFas in tuberculous pleural effusions was markedly higher than that in malignant pleural effusions ( t=6.80,P＜0.001;F= 4.451,t= 6.422, P＜0.001) . (3)The level of AM and CEA in tuberculous pleural effussions was markedly lower than that in malignant pleural effusions(t= 7.491, P＜0.05; t= 6.37, P＜0.01). Conclusion The joint detection of P-selectin, IL-1α, sFas,sFasL, AM and CEA might be helpful to differential diagnosis of tuberculosis pleural effusion and malignant pleural effusion.

Key words: P-secectin, IL-1α, sFas, sFasL, adrenomedullin ( AM ), Enzyme-linked immunosorbent assay (ELISA), Radioimmunoassay (RIA), Pleural effusion, tuberculosis, malignant peural effusions, Diagnosis

Wang Yingnian , Liu jiahong , Sun Rongli, et al.. The clinical diagnostic value of detection of P-selectin, IL-1α, sFas, sFasL, AM in differentiating tuberculous pleural effusions from malignant pleural effusions[J]. Chinese Journal of Antituberculosis, 2007, 29(1): 8-11.

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