Evaluation of AMPLICOR Test in diagnosis of tuberculosis by Meta analysis

Abstract

Abstract: Objective To evaluate the value of AMPLICOR test in the diagnosis of tuberculosis by meta analysis. Methods We searched Medline database and screened the papers related to diagnosis of tuberculosis by AM-PLICOR test, and then drew the summary receiver operating characteristic(SROC)by Sigmaplot, and analyzed data by Revman 4.2(a software from Cochrane). Finally, we compared DOR(Diagnostic Odd Ratio) of different golden standard and different sample types by nonparametric test. Results The data from 42 papers were analyzed. It showed that the sensitivity and specificity of AMPLICOR test were 81.2% and 96.0% , respectively. Tweenty-two papers were analyzed on the sensitivity and specificity of AMPLICOR test for smear-positive cases (sensitivity 97%, specificity 76.6% )and smear-negative cases(sensitivity 62.2% , specificity 99.3%). There were significant difference of DOR on using different golden standard and different sample types. Conclusion AMPLICOR test might be useful for the diagnoses of the smear-positive tuberculosis and smear-negative tuberculosis.

Key words: Meta analysis, AMPLICOR test, Tuberculosis, Diagnosis

Duan Hongfei, Fu Yu , Li Qi ,et al.. Evaluation of AMPLICOR Test in diagnosis of tuberculosis by Meta analysis[J]. Chinese Journal of Antituberculosis, 2007, 29(1): 56-60.

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