Abstract: Objective To determine the treatment outcome of drug-resistant pulmonary tuberculosis patients in Anyang of Henan province,so as to provide reference evidences for policy making for management of drug-resistant pulmonary patients in the future. Methods Retrospective analysis the information of drug-resistant pulmonary patients registered in Anyang Tuberculosis Dispensary from June 1994 to June 2004. Results Two hundred and twenty-one drug-resistant pulmonary tuberculosis patients registered in ten years.One hundred and fifteen cases were initial drug-resistance.One hundred and six cases were acquired drug-resistance;87 cases were resist to one drug,57 cases were resist to two drugs,77 cases were resist to three and more drugs.Sixty cases were multi-drug resistance cases.The treatment management of the cases are as followings: 177 cases with full-course management;44 cases with self-management.One hundred and twenty-two cases were prescribed with standardized regimens and 99 cases were prescribed with individual regimen.165 cases completed the treatment with regular drugs taking. 56 cases were default.The cure rate of 221 drug-resistance cases was 52.5%.The default rate was 25.3%.The cure rate of inital drug-resistant caseswas 67.0%.The cure rate of 1 drug resistance cases with standardized treatment regimen was 88.1%.The cure rate of acquired drug-resistance cases was 36.8%.Thecure rate of 1 drug resistance cases with standardized treatment regimen was 37.5%.The cure rate of multi-drug resistance cases was 30%.The cure rate of the patients who took medicine regularly was 70.3%. Conclusion The standardized treatment regimen have a higher effect to the initial drug-resistant patients,a lower effects to the acquired drug-resistant patients and MDR patients.The higher default rate is important impact factor for treatment outcome.We should be careful of selecting the individual regiment for the drug-resistance patients.We suggest that drug-resistance pulmonary tuberculosis patients should be registered separately and strengthen management to prevent treatment default so as to reduce the occurrence of hard to be treated cases.

Key words: Pulmonevry tuberculosis/prevention and control, drug-resistant, Treatment, Anyang city