Abstract: Objective To observe the treatment effects of polysaccharide-nucleic acid of BCG (BCG-PSN) as immune regulation preparation in patients with tuberculous pleural effusion. MethodThirty-eight tuberculous pleural effusion patients were divided into trial group and control group randomly. All patients were treated by pleurocentesis and the same chemotherapy regime, but the trial group was treated by pleurae cavum injection BCG-PSN. Before and after treatment, the effusion levels of Sil-2R were measured. ResultThe effusion levels of Sil-2R in two groups have no significant difference (P＜0.05) before treatment. After treatment 30 days, the effusion levels of Sil-2R in trial group decrease significantly (P＜0.05). At the end of the course, the fluid absorbed rates of the trial group and the control group were 95.5% and 68.7% respectively. The information above was significant in statistics (P＜0.05). ConclusionBCG-PSN can inhibit the extreme secretion of Sil-2R in tuberculous pleural fluid. By injection BCG-PSN in pleurae cavum, it can improve the fluid absorbed rate. There was no side effect observed during applying BCG-PSN in pleurae carum.

Key words: Tuberculous pleural, Effusion, Polysaccharide nucleic acid-BCG, Soluber Interleukin-2 receptor