Abstract:

Objective To investigate the efficacy and safety of urokinase washout uses alone and ozone + urokinase sequential drug washout program in the treatment of patients with tuberculous encapsulated pleural effusion. One hundred patients with tuberculous encapsulated pleural effusion were chosen in the period from January 2016 to December 2017 in Beijing Ditan Hospital affiliated to Capital Medical University and randomly divided into two groups including control group (n=50) and observation group (n=50). Patients in the control group were given urokinase washout program and those in the observation group were given ozone + urokinase sequential drug washout program assisted with thoracic drainage. The short-term efficacy, drainage time, disappearance time of pleural effusion, hospitalization time, pleural thickness and the levels of pleural effusion protein and WBC count before and after treatment and the frequency of adverse reactions of both groups were compared. The overall effective rate of the observation group after treatment was significant higher than that of the control group (92.0% (46/50) vs 74.0% (37/50); χ ²=9.78, P=0.01). The drainage time, disappearance time of pleural effusion and hospitalization time of the observation group after treatment were significant shorter than those of the control group ((8.42±1.04)d vs (32.35±4.50)d, (8.15±1.86)d vs (14.09±2.59)d, and (11.82±2.39)d vs (16.31±3.64)d, respectively; t=3.14, 3.90, and 4.11, respectively; all Ps<0.05). The pleural thickness and the levels of pleural effusion protein and WBC count after treatment of observation group were significant less than those of the control group ((1.78±0.35) mm vs (2.31±0.52) mm, (37.84±3.72) g/L vs (49.42±5.98) g/L, and (1.38±0.27)×10 ³/L vs (2.03±0.42)×10 ³/L, respectively; t=2.89, 3.12, and 3.50, respectively; all Ps<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (10.0% (5/50) vs 6.0% (3/50); χ ²=1.33, P=0.490). Compared with urokinase washout uses alone, ozone + urokinase sequential drug washout program in the treatment of patients with tuberculous encapsulated pleural effusion possess the better clinical efficacy.

Key words: Tuberculosis, Pleural effusion, Urokinase-type plasminogen activator, Ozone, Drainage