Abstract: Objective To evaluate the effect on liver function in pulmonary tuberculosis with positive HBVM treated with rifapentine or rifampicin.Method In HBVM positive group and negative group treated with rifapentine or rifampicin,liver function injury were observed before and after treatment.Results The incidence of liver injury in treated rifampicin group is higher than that in treated rifapentine group( P<0.01).The incidence of liver injury in HBVM positive group is higher than that in HBVM negative group( P<0 01).In treated rifampicin group,the incidence of liver injury in HBVM positive group is higher than that in HBVM negative group( P<0.01).In treated rifapentine group showed liver injury no significant differences( P >0 05).Conclusion The incidence of liver injury in HBVM positive group is higher than that in HBVM negative group because liver injury exists in the former before treatment.In the treatment of pulmonary tuberculosis,using rifapentine is better and safer.

Key words: Tuberculosis, pulmouary, HBVM, Rifamycin agents