The research progress of biomarkers in cerebrospinal fluid for diagnosis of tuberculous meningitis

doi:10.3969/j.issn.1000-6621.2021.12.017

Abstract

Abstract:

The non-specific clinical manifestations and imaging changes of tuberculous meningitis (TBM) as well as the lack of efficient laboratory diagnostic approaches make the diagnosis of TBM extremely difficult. However, early diagnosis of TBM is extremely crucial for timely treatment and improvement of prognosis. There are many biomarkers in cerebrospinal fluid (CSF) which have potential value for early diagnosis of TBM. In this paper, we mainly reviewed and discussed the study progresses and challenges of using host biomarkers in CSF on TBM diagnosis.

Key words: Tuberculosis,meningeal, Cerebrospinal fluid, Host specificity, Biomarkers, Diagnosis

CHEN Meng-meng, DONG Jing, JIA Hong-yan, ZHAGN Zong-de, PAN Li-ping. The research progress of biomarkers in cerebrospinal fluid for diagnosis of tuberculous meningitis[J]. Chinese Journal of Antituberculosis, 2021, 43(12): 1327-1331. doi: 10.3969/j.issn.1000-6621.2021.12.017

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