Chinese Journal of Antituberculosis ›› 2021, Vol. 43 ›› Issue (11): 1107-1112.doi: 10.3969/j.issn.1000-6621.2021.11.001
• Guideline∙Standard∙Consensus • Previous Articles Next Articles
Beijing Chest Hospital,Capital Medical University,Editorial Board of Chinese Journal of Antituberculosis
Received:
2021-08-04
Online:
2021-11-10
Published:
2021-11-02
Beijing Chest Hospital,Capital Medical University,Editorial Board of Chinese Journal of Antituberculosis . Expert consensus on polymorphism detection of N-acetyltransferase-2 encoding gene and appropriate isoniazid dosing for tuberculosis patients[J]. Chinese Journal of Antituberculosis, 2021, 43(11): 1107-1112. doi: 10.3969/j.issn.1000-6621.2021.11.001
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基因型 | 代谢类型 |
---|---|
341T→C位点、590G→A位点、857G→A位点均为野生型 | 快代谢型 |
341T→C位点为杂合突变型 | 中间代谢型 |
590G→A位点为杂合突变型 | 中间代谢型 |
857G→A位点为杂合突变型 | 中间代谢型 |
341T→C位点和590G→A位点为杂合突变型 | 中间代谢型或慢代谢型 |
341T→C位点和857G→A位点为杂合突变型 | 中间代谢型或慢代谢型 |
590G→A位点和857G→A位点为杂合突变型 | 中间代谢型或慢代谢型 |
341T→C位点、590G→A位点、857G→A位点为杂合突变型 | 中间代谢型或慢代谢型 |
341T→C位点为纯合突变型,其他2个位点任意情况 | 慢代谢型 |
590G→A位点为纯合突变型,其他2个位点任意情况 | 慢代谢型 |
857G→A位点为纯合突变型,其他2个位点任意情况 | 慢代谢型 |
代谢类型 | 用药建议 |
---|---|
快代谢型 | 异烟肼在人体内代谢速度加快,血液中活性成分消除加快,建议可考虑使用1.5倍标准剂量的异烟肼治疗;也可综合患者的身体指标、病程情况,使用标准剂量的异烟肼,同步测定患者的异烟肼血药浓度,并根据具体情况进行调整 |
中间代谢型 | 建议使用标准剂量的异烟肼进行治疗;也可综合患者的身体指标、病程情况,使用标准剂量的异烟肼,同步测定患者的异烟肼血药浓度,并根据具体情况进行调整 |
慢代谢型 | NAT2基因突变导致异烟肼代谢减慢,异烟肼短期内在人体内积累,血药浓度高,杀菌效果好,但异烟肼高浓度积累会对肝脏造成损伤,建议考虑治疗时降低用量至0.5倍的标准剂量;也可综合患者的身体指标、病程情况,使用标准剂量的异烟肼,同步测定患者的异烟肼血药浓度,并根据具体情况进行调整 |
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