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Chinese Journal of Antituberculosis ›› 2026, Vol. 48 ›› Issue (3): 419-425.doi: 10.19982/j.issn.1000-6621.20250397

• Review Articles • Previous Articles     Next Articles

Research progress on the mechanisms of lung injury caused by Mycobacterium abscessus

Ni Sheng1, Sha Wei2, Wang Li2()   

  1. 1Tongji University School of Medicine, Shanghai 200092, China
    2Department of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, TongJi University, Shanghai 200433, China
  • Received:2025-10-09 Online:2026-03-10 Published:2026-03-06
  • Contact: Wang Li E-mail:wangli_shph@tongji.edu.cn
  • Supported by:
    National Key R&D Program of China (Pathogen Research)-Sub-project(2023YFC2307303);Fundamental Research Funds for the Central Universities(Tongji University Independent Original Basic Research 22120240329);Shanghai Shenkang Hospital Development Center Municipal Hospital Clinical Research and Management Optimization Program(SHDC12022108)

Abstract:

Mycobacterium abscessus complex (MABC) has high virulence and high drug resistance. The mechanisms of lung injury causing by MABC are complicated, mainly caused by the imbalance of host immune response and abnormal tissue repair. This review summarizes current researches on the mechanisms of MABC-induced lung injury, focusing especially on the roles of excessive inflammatory responses and abnormal repair processes, to identify crucial points of the disease development, to set the stage for more focused researches into particular pathogenic stages.

Key words: Mycobacterium abscessus, Infection, Immunity, Review

CLC Number: