Chinese Journal of Antituberculosis ›› 2026, Vol. 48 ›› Issue (1): 148-152.doi: 10.19982/j.issn.1000-6621.20250358
• Review Articles • Previous Articles Next Articles
Fu Yanan1, Yang Xiaotao1, Liu Xiaomei1(
), Shen Adong1,2(
)
Received:2025-09-07
Online:2026-01-10
Published:2025-12-31
Contact:
Liu Xiaomei,Shen Adong
E-mail:1043443230@qq.com;shenad16@hotmail.com
Supported by:CLC Number:
Fu Yanan, Yang Xiaotao, Liu Xiaomei, Shen Adong. Research progress in drug-susceptible pulmonary tuberculosis treatment regimens for children[J]. Chinese Journal of Antituberculosis, 2026, 48(1): 148-152. doi: 10.19982/j.issn.1000-6621.20250358
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.zgflzz.cn/EN/10.19982/j.issn.1000-6621.20250358
| [1] | 胡鑫洋, 高静韬. 世界卫生组织《2024年全球结核病报告》解读. 结核与肺部疾病杂志, 2024, 5 (6): 500-504. doi:10.19983/j.issn.2096-8493.2024164. |
| [2] |
Zhang Y, Zhan B, Hao X, et al. Factors associated with diagnostic delay of pulmonary tuberculosis among children and adolescents in Quzhou, China: results from the surveillance data 2011-2021.. BMC Infect Dis, 2023, 23(1): 541. doi:10.1186/s12879-023-08516-1.
pmid: 37596514 |
| [3] | Starshinova A. Difficulties in diagnosing tuberculosis infection in childhood. Lancet Infect Dis, 2025, 25(2): 140-141. doi:10.1016/s1473-3099(24)00569-3. |
| [4] | World Health Organization. WHO consolidated guidelines on tuberculosis: module 4: treatment: drug-susceptible tuberculosis treatment. Geneva: World Health Organization, 2022. |
| [5] | World Health Organization. Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2nd ed. Geneva: World Health Organization, 2014. |
| [6] |
Graham SM, Amanullah F. Updated guidelines for child and adolescent TB. Int J Tuberc Lung Dis, 2022, 26(2): 81-84. doi:10.5588/ijtld.21.0747.
pmid: 35086615 |
| [7] | Gafar F, Wasmann RE, McIlleron HM, et al. Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis. Eur Respir J, 2023, 61(3). doi:10.1183/13993003.01596-2022. |
| [8] |
White YN, Solans BP, Denti P, et al. Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis. Clin Infect Dis, 2024, 78(3): 756-764. doi:10.1093/cid/ciae024.
pmid: 38340060 |
| [9] | Burman W, Luczynski P, Horsburgh CR, et al. Representativeness and adverse event reporting in late-phase clinical trials for rifampin-susceptible tuberculosis: a systematic review. Lancet Infect Dis, 2025, 25(2): e86-e98. doi:10.1016/s1473-3099(24)00597-8. |
| [10] |
Solans BP, Béranger A, Radtke K, et al. Effectiveness and Pharmacokinetic Exposures of First-Line Drugs Used to Treat Drug-Susceptible Tuberculosis in Children: A Systematic Review and Meta-Analysis. Clin Infect Dis, 2023, 76(9): 1658-1670fc. doi:10.1093/cid/ciac973.
pmid: 36609692 |
| [11] | Sabella-Jiménez V, Hoyos Mendez Y, Benjumea-Bedoya D, et al. Effectiveness and safety of available preventive tuberculosis treatment regimens for children and adolescents: protocol for a systematic review and network meta-analysis. BMJ Paediatr Open, 2022, 6(1). doi:10.1136/bmjpo-2022-001551. |
| [12] |
Imperial MZ, Nahid P, Phillips PPJ, et al. A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis. Nat Med, 2018, 24(11): 1708-1715. doi:10.1038/s41591-018-0224-2.
pmid: 30397355 |
| [13] | Silva DR, Mello FCQ, Migliori GB. Shortened tuberculosis treatment regimens: what is new? J Bras Pneumol, 2020, 46(2): e20200009. doi:10.36416/1806-3756/e20200009. |
| [14] | Yerramsetti S, Cohen T, Atun R, et al. Global estimates of paediatric tuberculosis incidence in 2013-19: a mathematical modelling analysis. Lancet Glob Health, 2022, 10(2): e207-e215. doi:10.1016/s2214-109x(21)00462-9. |
| [15] | Prodanuk M, Silverberg SL, Piché-Renaud PP, et al. Adverse events of first-line therapy for pediatric tuberculosis: A systematic review and meta-analysis. Clin Infect Dis, 2025. doi:10.1093/cid/ciaf152. |
| [16] | Zhuang Z, Sun L, Song X, et al. Trends and challenges of multi-drug resistance in childhood tuberculosis. Front Cell Infect Microbiol, 2023, 13: 1183590. doi:10.3389/fcimb.2023.1183590. |
| [17] | Controlled trial of 4 three-times-weekly regimens and a daily regimen all given for 6 months for pulmonary tuberculosis. Second report: the results up to 24 months. Hong Kong Chest Service/British Medical Research Council. Tubercle, 1982, 63(2): 89-98. doi:10.1016/s0041-3879(82)80044-5. |
| [18] | World Health Organization. Treatment of tuberculosis: guidelines for national programmes, 2nd ed. Geneva: World Health Organization, 1997. |
| [19] |
Girling DJ, Caulet P, Pamra SP, et al. Anti-tuberculosis regimens of chemotherapy. Recommendations from the Committee on Treatment of the International Union against Tuberculosis and Lung Disease. Indian J Chest Dis Allied Sci, 1988, 30(4): 296-304.
pmid: 3076583 |
| [20] | World Health Organization. Treatment of tuberculosis:Guidelines for national programmes:third edition. Geneva: World Health Organization, 2003. |
| [21] | World Health Organization. Guidance for national tuberculosis programmes on the management of tuberculosis in children. Geneva: World Health Organization, 2006 |
| [22] |
Driver CR, Munsiff SS, Li J, et al. Relapse in persons treated for drug-susceptible tuberculosis in a population with high coinfection with human immunodeficiency virus in New York City. Clin Infect Dis, 2001, 33(10): 1762-1769. doi:10.1086/323784.
pmid: 11595988 |
| [23] | World Health Organization. Rapid advice: treatment of tuberculosis in children. Geneva: World Health Organization, 2010. |
| [24] | 焦伟伟, 申阿东. 儿童结核病药物治疗现状及进展. 中华实用儿科临床杂志, 2020, 35(10): 753-758. doi:10.3760/cma.j.cn101070-20200525-00883. |
| [25] | Menzies D, Benedetti A, Paydar A, et al. Effect of duration and intermittency of rifampin on tuberculosis treatment outcomes: a systematic review and meta-analysis. PLoS Med, 2009, 6(9): e1000146. doi:10.1371/journal.pmed.1000146. |
| [26] | Menzies D, Benedetti A, Paydar A, et al. Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: a systematic review and meta-analysis. PLoS Med, 2009, 6(9): e1000150. doi:10.1371/journal.pmed.1000150. |
| [27] |
Thee S, Seddon JA, Donald PR, et al. Pharmacokinetics of isoniazid, rifampin, and pyrazinamide in children younger than two years of age with tuberculosis: evidence for implementation of revised World Health Organization recommendations. Antimicrob Agents Chemother, 2011, 55(12): 5560-5567. doi:10.1128/aac.05429-11.
pmid: 21968358 |
| [28] | Donald PR, Maritz JS, Diacon AH. The pharmacokinetics and pharmacodynamics of rifampicin in adults and children in relation to the dosage recommended for children. Tuberculosis (Edinb), 2011, 91(3): 196-207. doi:10.1016/j.tube.2011.02.004. |
| [29] |
McIlleron H, Willemse M, Werely CJ, et al. Isoniazid plasma concentrations in a cohort of South African children with tuberculosis: implications for international pediatric dosing guidelines. Clin Infect Dis, 2009, 48(11): 1547-1553. doi:10.1086/598192.
pmid: 19392636 |
| [30] | Donald PR. Antituberculosis drug-induced hepatotoxicity in children. Pediatr Rep, 2011, 3(2): e16. doi:10.4081/pr.2011.e16. |
| [31] | World Health Organization. Ethambutol efficacy and toxicity: literature review and recommendations for daily and intermittent dosage in children. Geneva: World Health Organization, 2006. |
| [32] | 徐彩红, 张文宏, 赵雁林. 《全国结核病防治规划(2024—2030年)》开启我国结核病防治工作新篇章. 中华传染病杂志, 2024, 42(12): 705-710. doi:10.3760/cma.j.cn311365-20250122-00026. |
| [33] | 陈伟, 李雪, 刘小秋, 等. 《全国结核病防治规划(2024—2030年)》解读. 中国防痨杂志, 2025, 47(2): 130-136. doi:10.19982/j.issn.1000-6621.20240585. |
| [34] | Gillespie SH, Crook AM, McHugh TD, et al. Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis. N Engl J Med, 2014, 371(17): 1577-1587. doi:10.1056/NEJMoa1407426. |
| [35] | Merle CS, Fielding K, Sow OB, et al. A four-month gatifloxacin-containing regimen for treating tuberculosis. N Engl J Med, 2014, 371(17): 1588-1598. doi:10.1056/NEJMoa1315817. |
| [36] | Jindani A, Harrison TS, Nunn AJ, et al. High-dose rifapentine with moxifloxacin for pulmonary tuberculosis. N Engl J Med, 2014, 371(17):1599-1608. doi:10.1056/NEJMoa1314210. |
| [37] | Dorman SE, Nahid P, Kurbatova EV, et al. Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis. N Engl J Med, 2021, 384(18): 1705-1718. doi:10.1056/NEJMoa2033400. |
| [38] | Turkova A, Wills GH, Wobudeya E, et al. Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children. N Engl J Med, 2022, 386(10): 911-922. doi:10.1056/NEJMoa2104535. |
| [39] | 中华医学会结核病学分会. 抗结核药物超说明书用法专家共识(2023年更新版). 中华结核和呼吸杂志, 2023, 46(11): 1085-1102. doi:10.3760/cma.j.cn112147-20230809-00062. |
| [40] | 贺晓新, 李波, 周林. 《4个月含利福喷丁抗结核治疗方案疗效观察》解读. 中国防痨杂志, 2021, 43(12): 1243-1247. doi:10.3969/j.issn.1000-6621.2021.12.004. |
| [41] | 中国防痨协会, 中华医学会结核病学分会儿童结核病专业委员会, 中国研究型医院学会结核病学专业委员会, 等. 儿童和青少年药物敏感结核病化学治疗专家共识. 中华实用儿科临床杂志, 2024, 39(9): 641-645. doi:10.3760/cma.j.cn101070-20240529-00334. |
| [42] | World Health Organization. WHO consolidated guidelines on tuberculosis: module 4: treatment and care. Geneva: World Health Organization, 2025. |
| [43] | 黄涛, 陈晴, 吴桂辉, 等. 世界卫生组织2025年版《结核病整合指南模块4:治疗与关怀》解读. 中华结核和呼吸杂志, 2025, 48(8): 708-718. doi:10.3760/cma.j.cn112147-20250512-00259. |
| [44] | Aguilar Diaz JM, Abulfathi AA, Te Brake LH, et al. New and Repurposed Drugs for the Treatment of Active Tuberculosis: An Update for Clinicians. Respiration, 2023, 102(2): 83-100. doi:10.1159/000528274. |
| [45] | Saluzzo F, Adepoju VA, Duarte R, et al. Treatment-shortening regimens for tuberculosis: updates and future priorities. Breathe (Sheff), 2023, 19(3): 230028. doi:10.1183/20734735.0028-2023. |
| [46] |
Svensson RJ, Svensson EM, Aarnoutse RE, et al. Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations. J Infect Dis, 2018, 218(6): 991-999. doi:10.1093/infdis/jiy242.
pmid: 29718390 |
| [47] | Ranganathan UD, Smith-Jeffcoat SE, Balaji S, et al. High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment. JAC Antimicrob Resist, 2025, 7(3): dlaf072. doi:10.1093/jacamr/dlaf072. |
| [1] | Multidisciplinary Diagnosis and Treatment Branch of Chinese Antituberculosis Association , National Clinical Research Center for Infectious Disease/Shenzhen Third People’s Hospital , Beijing Chao-Yang Hospital, Capital Medical University , Guangdong Lung Cancer Institute . Expert consensus on the diagnosis and treatment of coexistent pulmonary tuberculosis and lung cancer [J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1105-1125. |
| [2] | Wang Lin, Qu Yan. Research progress on hospital infection prevention and control of multidrug-resistant organisms [J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1196-1203. |
| [3] | Lai Xiaoyu, Duan Hongfei, Chen Xunxun, Guo Huixin, Liao Qinghua, Chen Qian, Liang Dan. Clinical characteristics, diagnostic strategies, and advances in grading criteria for tubercular uveitis [J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1204-1211. |
| [4] | Wang Huijuan, Cheng Ruixia, Xu jia. Research progress on medication adherence in patients with pulmonary tuberculosis [J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1212-1219. |
| [5] | Chen Liyao, Peng Xiao, Liu Yuanyuan, Shi Jin, Guo Yongli, Lu Jie. The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis [J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1227-1232. |
| [6] | Zhu Qingdong, Zhao Chunyan, Xie Zhouhua, Song Shulin, Song Chang. Research progress on the application of artificial intelligence-based CT radiomics in the diagnosis and treatment response monitoring of tuberculosis [J]. Chinese Journal of Antituberculosis, 2025, 47(8): 1068-1076. |
| [7] | Meng Qinglin, Wang Yunxia, Tang Yan, Liu Eryong. Analysis of psychological support of tuberculosis patients at home and abroad [J]. Chinese Journal of Antituberculosis, 2025, 47(8): 981-985. |
| [8] | Tang Lingling, Chen Danping, Li Yuru, Jiang Hua, Huang Le, Su Limin. Analysis of family functioning of patients with drug-resistant pulmonary tuberculosis and its influencing factors [J]. Chinese Journal of Antituberculosis, 2025, 47(8): 999-1006. |
| [9] | Chinese Antituberculosis Association, Editorial Board of Chinese Journal of Antituberculosis, Beijing Chest Hospital Capital Medlical University/Beijing Tuberculosis and Thoracic Tumor Research Institute. Expert consensus on all-oral short-course therapy for drug-resistant tuberculosis [J]. Chinese Journal of Antituberculosis, 2025, 47(7): 830-839. |
| [10] | Wang Meiji, Liu Meijun, Chen Rui, Xia Lu, Liu Xuhui, Yang Yang, Liu Huarui, Ye Dan, Fei Zhentao, Xie Shiqi, Yang Shuqi, Pan Lei, Zhang Xiaolin, Xu Biao, Li Feng. Functional outcomes and predictors of tuberculous meningitis in children and young adolescents: a hospital-based retrospective study [J]. Chinese Journal of Antituberculosis, 2025, 47(7): 907-913. |
| [11] | Liu Yiping, Lin Youfei, Chen Xiaohong, Pan Jianguang. A case of pulmonary Castleman disease prone to misdiagnosis: a literature review [J]. Chinese Journal of Antituberculosis, 2025, 47(7): 921-929. |
| [12] | Wang Yutong, Liu Yuhong, Li Liang. Research progress on psychological and psychiatric adverse reactions induced by antituberculosis drugs [J]. Chinese Journal of Antituberculosis, 2025, 47(7): 947-953. |
| [13] | Huang Weiqiang, Yuan Chuchu, Zhang Huan, Wang Lili, Zhong Xiaofeng, Chen Xingxing, Hu Ming. Analysis of blood concentrations of intravenous antituberculosis drugs in 45 mechanically ventilated patients with severe tuberculosis [J]. Chinese Journal of Antituberculosis, 2025, 47(6): 798-807. |
| [14] | Zhang Peize, Gao Qian, Deng Guofang. [18F]FDT-PET-CT technology that may bring revolutionary changes to tuberculosis clinical research [J]. Chinese Journal of Antituberculosis, 2025, 47(3): 262-265. |
| [15] | Zhu Jiankun, Meng Qian, Kong Kangbao, Jin Feng. The value of pneumonectomy in the treatment of pulmonary mucormycosis [J]. Chinese Journal of Antituberculosis, 2025, 47(3): 274-281. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
京公网安备11010202007215号
Total visitors: Visitors of today: Now online:
This work is licensed under Creative Commons Attribution 3.0 License.