Exploring diagnostic and therapeutic approaches for latent tuberculosis infection based on the theory of hidden pathogen (Fu Xie)

doi:10.19982/j.issn.1000-6621.20250327

Abstract

Abstract:

In Traditional Chinese Medicine (TCM) categorizes tuberculosis (TB) as “consumptive disease” (lao bing) or “consumptive disorder” (lao zhai). Latent tuberculosis infection (LTBI) is the primary source of TB onset and a continuous reservoir of new cases. LTBI presents with concealed clinical symptoms, aligning with the characteristics of “latent pathogen”(fu xie) in TCM. Authors review the origin and core principles of the latent pathogen theory, correspondence with the latent biological features of Mycobacterium tuberculosis. On this basis, a TCM diagnostic and therapeutic approach of “treatment based on stage differentiation”(fen qi bian zhi) and “syndrome-based treatment”(fen zheng lun zhi) is proposed, aiming to provide theoretical references for the early intervention of LTBI with TCM, regulation of immune homeostasis, and further reduction of TB incidence.

Key words: Mycobacterium infections, Medicine, Chinese traditional, Consensus development conferences as topic

CLC Number:

R2-03
R521

Feng Yinping, Zhang Zunjing, Cai Qiujie, Wang Xiaomeng, Ma Yan, Liu Zhongda, Gao Lei. Exploring diagnostic and therapeutic approaches for latent tuberculosis infection based on the theory of hidden pathogen (Fu Xie)[J]. Chinese Journal of Antituberculosis, 2025, 47(10): 1249-1253. doi: 10.19982/j.issn.1000-6621.20250327

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