Research progresses of risk factors for tuberculosis in the elderly

doi:10.19982/j.issn.1000-6621.20240255

Abstract

Abstract:

As China experiences rapid aging and faces specific challenges among its elderly population, including reduced immune function, malnutrition, co-morbidities, and limited access to health services, tuberculosis (TB) among the elderly has become a critical focus for TB prevention and control. Examining the prevalence of TB in the elderly and identifying its associated risk factors are essential for effective etiological prevention, targeted prevention and control strategies, and the reduction of TB incidence among the elderly. This paper analyzed the prevalence of TB in the elderly in China and reviewed relevant literature on its risk factors. The aim was to provide a basis for the formulation of future TB prevention and control strategies and to support related research.

Key words: Tuberculosis, Aged, Risk factors

CLC Number:

R183.3

Zhang Mengdi, Wang Xin, Zheng Wenjing, Wang Qiqi, Li Tao, Wang Ni, Liu Jianjun, Huang Fei, Yao Hongyan. Research progresses of risk factors for tuberculosis in the elderly[J]. Chinese Journal of Antituberculosis, 2024, 46(10): 1266-1272. doi: 10.19982/j.issn.1000-6621.20240255

References 74

[1]	李立明. 流行病学. 北京: 人民卫生出版社, 2017.
[2]	舒薇, 刘宇红. 世界卫生组织《2023年全球结核病报告》解读. 结核与肺部疾病杂志, 2024, 5 (1): 15-19. doi:10.19983/j.issn.2096-8493.2024006.
[3]	宁吉喆. 第七次全国人口普查主要数据情况. 中国统计, 2021, 36(5): 4-5.
[4]	姜世闻. 重视老年人结核病防治工作. 结核病与肺部健康杂志, 2018, 7(3): 157-160. doi:10.3969/j.issn.2095-3755.2018.03.002.
[5]	张灿有, 陈卉, 张慧, 等. 2011—2020年全国65岁及以上老年人肺结核报告发病情况分析. 中华疾病控制杂志, 2022, 26(11): 1252-1258. doi:10.16462/j.cnki.zhjbkz.2022.11.003.
[6]	全国第五次结核病流行病学抽样调查技术指导组,全国第五次结核病流行病学抽样调查办公室. 2010年全国第五次结核病流行病学抽样调查报告. 中国防痨杂志, 2012, 34(8): 485-508.
[7]	全国结核病流行病学抽样调查技术指导组,全国结核病流行病学抽样调查办公室. 2000年全国结核病流行病学抽样调查报告. 中国防痨杂志, 2002, 24(2): 65-108.
[8]	Horton KC, MacPherson P, Houben RM, et al. Sex Diffe-rences in Tuberculosis Burden and Notifications in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis. PLoS Med, 2016, 13(9): e1002119. doi:10.1371/journal.pmed.1002119.
[9]	Cheng J, Sun YN, Zhang CY, et al. Incidence and risk factors of tuberculosis among the elderly population in China: a prospective cohort study. Infect Dis Poverty, 2020, 9(1): 13. doi:10.1186/s40249-019-0614-9. pmid: 32005290
[10]	张碧波, 李洪海. 2011—2017年黑龙江省老年肺结核疫情特征分析. 结核病与肺部健康杂志, 2018, 7(4): 293-297. doi:10.3969/j.issn.2095-3755.2018.04.014.
[11]	蔡晓婷, 江坤洪, 何立乾, 等. 广州市海珠区老年人肺结核筛查结果分析. 结核与肺部疾病杂志, 2024, 5(3): 244-248. doi:10.19983/j.issn.2096-8493.2024075.
[12]	Centers for Disease Control and Prevention. Reported Tuberculosis in the United States. Atlanta: Centers for Disease Control and Prevention, 2021.
[13]	Nanoo A, Izu A, Ismail NA, et al. Nationwide and regional incidence of microbiologically confirmed pulmonary tuberculosis in South Africa, 2004-12: a time series analysis. Lancet Infect Dis, 2015, 15(9): 1066-1076. doi:10.1016/S1473-3099(15)00147-4. pmid: 26112077
[14]	Neyrolles O, Quintana-Murci L. Sexual inequality in tuberculosis. PLoS Med, 2009, 6(12):e1000199. doi:10.1371/journal.pmed.1000199.
[15]	Zellweger JP, Cattamanchi A, Sotgiu G. Tobacco and tuberculosis: could we improve tuberculosis outcomes by helping patients to stop smoking?. Eur Respir J, 2015, 45(3): 583-585. doi:10.1183/09031936.00221814.
[16]	Leung CC, Li T, Lam TH, et al. Smoking and tuberculosis among the elderly in Hong Kong. Am J Respir Crit Care Med, 2004, 170(9): 1027-1033. doi:10.1164/rccm.200404-512OC.
[17]	Nisar M, Williams CS, Ashby D, et al. Tuberculin testing in residential homes for the elderly. Thorax, 1993, 48(12): 1257-1260. doi:10.1136/thx.48.12.1257. pmid: 8303634
[18]	Feng Y, Kong Y, Barnes PF, et al. Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis. Infect Immun, 2011, 79(1): 229-237. doi:10.1128/IAI.00709-10. pmid: 20974820
[19]	Strzelak A, Ratajczak A, Adamiec A, et al. Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. Int J Environ Res Public Health, 2018, 15(5): 1033. doi:10.3390/ijerph15051033.
[20]	Jeon CY, Murray MB. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med, 2008, 5(7): e152. doi:10.1371/journal.pmed.0050152.
[21]	Harries AD, Satyanarayana S, Kumar AM, et al. Epidemiology and interaction of diabetes mellitus and tuberculosis and challenges for care: a review. Public Health Action, 2013, 3(Suppl 1): S3-S9. doi:10.5588/pha.13.0024.
[22]	Lee PH, Fu H, Lee MR, et al. Tuberculosis and diabetes in low and moderate tuberculosis incidence countries. Int J Tuberc Lung Dis, 2018, 22(1): 7-16. doi:10.5588/ijtld.17.0329. pmid: 29297421
[23]	Ruslami R, Aarnoutse RE, Alisjahbana B, et al. Implications of the global increase of diabetes for tuberculosis control and patient care. Trop Med Int Health, 2010, 15(11): 1289-1299. doi:10.1111/j.1365-3156.2010.02625.x. pmid: 20955495
[24]	Lönnroth K, Roglic G, Harries AD. Improving tuberculosis prevention and care through addressing the global diabetes epidemic: from evidence to policy and practice. Lancet Diabetes Endocrinol, 2014, 2(9): 730-739. doi:10.1016/S2213-8587(14)70109-3.
[25]	Zhang CY, Zhao F, Xia YY, et al. Prevalence and risk factors of active pulmonary tuberculosis among elderly people in China: a population based cross-sectional study. Infect Dis Poverty, 2019, 8(1): 7. doi:10.1186/s40249-019-0515-y.
[26]	陈丹珊, 梁玉欣, 周忠敬, 等. 黄埔某些社区老年糖尿病患者结核病筛查情况分析. 中国社区医师, 2023, 39(8): 145-147. doi:10.3969/j.issn.1007-614x.2023.08.049.
[27]	Kim SJ, Hong YP, Lew WJ, et al. Incidence of pulmonary tuberculosis among diabetics. Tuber Lung Dis, 1995, 76(6): 529-533. doi:10.1016/0962-8479(95)90529-4.
[28]	Ponce-De-Leon A, Garcia-Garcia Md Mde L, Garcia-Sancho MC, et al. Tuberculosis and diabetes in southern Mexico. Diabetes Care, 2004, 27(7): 1584-1590. doi:10.2337/diacare.27.7.1584. pmid: 15220232
[29]	Silva DR, Muñoz-Torrico M, Duarte R, et al. Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs. J Bras Pneumol, 2018, 44(2): 145-152. doi:10.1590/s1806-37562017000000443. pmid: 29791552
[30]	Lee PH, Fu H, Lai TC, et al. Glycemic Control and the Risk of Tuberculosis: A Cohort Study. PLoS Med, 2016, 13(8): e1002072. doi:10.1371/journal.pmed.1002072.
[31]	Martens GW, Arikan MC, Lee J, et al. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol, 2007, 37(5): 518-524. doi:10.1165/rcmb.2006-0478OC.
[32]	Delamaire M, Maugendre D, Moreno M, et al. Impaired leucocyte functions in diabetic patients. Diabet Med, 1997, 14(1): 29-34. doi:10.1002/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V.
[33]	Rayfield EJ, Ault MJ, Keusch GT, et al. Infection and diabetes: the case for glucose control. Am J Med, 1982, 72(3): 439-450. doi:10.1016/0002-9343(82)90511-3. pmid: 7036735
[34]	Chen J, Zha S, Hou J, et al. Dose-response relationship between body mass index and tuberculosis in China: a population-based cohort study. BMJ Open, 2022, 12(3): e050928. doi:10.1136/bmjopen-2021-050928.
[35]	Cegielski JP, McMurray DN. The relationship between malnutrition and tuberculosis: evidence from studies in humans and experimental animals. Int J Tuberc Lung Dis, 2004, 8(3): 286-298. pmid: 15139466
[36]	Niki M, Yoshiyama T, Nagai H, et al. Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development. PLoS One, 2020, 15(8): e0237062. doi:10.1371/journal.pone.0237062.
[37]	Zittermann A, Pilz S, Hoffmann H, et al. Vitamin D and airway infections: a European perspective. Eur J Med Res, 2016, 21: 14. doi:10.1186/s40001-016-0208-y. pmid: 27009076
[38]	Djoko KY, Ong CL, Walker MJ, et al. The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens. J Biol Chem, 2015, 290(31): 18954-18961. doi:10.1074/jbc.R115.647099. pmid: 26055706
[39]	Aibana O, Franke MF, Huang CC, et al. Vitamin E Status Is Inversely Associated with Risk of Incident Tuberculosis Disease among Household Contacts. J Nutr, 2018, 148(1): 56-62. doi:10.1093/jn/nxx006. pmid: 29378042
[40]	Rehm J, Samokhvalov AV, Neuman MG, et al. The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review. BMC Public Health, 2009, 9: 450. doi:10.1186/1471-2458-9-450. pmid: 19961618
[41]	Lönnroth K, Williams BG, Stadlin S, et al. Alcohol use as a risk factor for tuberculosis-a systematic review. BMC Public Health, 2008, 8: 289. doi:10.1186/1471-2458-8-289. pmid: 18702821
[42]	Xin H, Zhang H, Liu J, et al. Mycobacterium Tuberculosis infection among the elderly in 20 486 rural residents aged 50-70 years in Zhongmu County, China. Clin Microbiol Infect, 2019, 25(9): 1120-1126. doi:10.1016/j.cmi.2019.01.021.
[43]	赵晔, 张莹晖, 范丽珺, 等. 哈尔滨市60岁以上老年人结核病发病危险因素病例对照研究. 中国公共卫生管理, 2011, 27(3): 321-323. doi:10.19568/j.cnki.23-1318.2011.03.057.
[44]	Righi E, Della Siega P, Merelli M, et al. Comparison of clinical characteristics of tuberculosis between two age groups at an Italian Tertiary Hospital. Infection, 2015, 43(3): 361-366. doi:10.1007/s15010-015-0765-y. pmid: 25808263
[45]	Soh AZ, Chee CBE, Wang YT, et al. Alcohol drinking and cigarette smoking in relation to risk of active tuberculosis: prospective cohort study. BMJ Open Respir Res, 2017, 4(1): e000247. doi:10.1136/bmjresp-2017-000247.
[46]	Joshi PC, Applewhite L, Ritzenthaler JD, et al. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. J Immunol, 2005, 175(10): 6837-6845. doi:10.4049/jimmunol.175.10.6837. pmid: 16272341
[47]	Gamble L, Mason CM, Nelson S. The effects of alcohol on immunity and bacterial infection in the lung. Med Mal Infect, 2006, 36(2): 72-77. doi:10.1016/j.medmal.2005.08.010.
[48]	Szabo G, Saha B. Alcohol’s Effect on Host Defense. Alcohol Res, 2015, 37(2): 159-170.
[49]	Reichler MR, Reves R, Bur S, et al. Evaluation of investigations conducted to detect and prevent transmission of tuberculosis. JAMA, 2002, 287(8): 991-995. doi:10.1001/jama.287.8.991.
[50]	Velen K, Shingde RV, Ho J, et al. The effectiveness of contact investigation among contacts of tuberculosis patients: a systematic review and meta-analysis. Eur Respir J, 2021, 58(6): 2100266. doi:10.1183/13993003.00266-2021.
[51]	王丽丽. 老年肺结核危险因素及风险预测. 中国保健营养, 2023, 33(9): 206-209.
[52]	张家泳, 丛守婧, 王涛, 等. 中国肺结核患者家庭密切接触者活动性肺结核检出情况的Meta分析. 中国防痨杂志, 2016, 38(10): 862-868. doi:10.3969/j.issn.1000-6621.2016.10.015.
[53]	谢欣, 唐利红, 黄晓霞, 等. 上海市某区菌阳肺结核患者密切接触者结核分枝杆菌潜伏感染及其相关因素. 中华结核和呼吸杂志, 2016, 39(12): 944-947. doi:10.3760/cma.j.issn.1001-0939.2016.12.008.
[54]	Shen X, Yang C, Wu J, et al. Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection?. Tuberculosis (Edinb), 2017, 103: 97-104. doi:10.1016/j.tube.2017.01.007.
[55]	Chan-Yeung M, Cheung AH, Dai DL, et al. Prevalence and determinants of positive tuberculin reactions of residents in old age homes in Hong Kong. Int J Tuberc Lung Dis, 2006, 10(8): 892-898. pmid: 16898374
[56]	Chen J, Cao W, Chen R, et al. Prevalence and determinants of HIV in tuberculosis patients in Wuxi City, Jiangsu province, China: a cross-sectional study. Int J STD AIDS, 2016, 27(13): 1204-1212. doi:10.1177/0956462415612618. pmid: 26482328
[57]	World Health Organization. Tuberculosis fact sheet. Geneva: World Health Organization, 2023.
[58]	Kirirabwa NS, Kimuli D, DeJene S, et al. Response to anti-tuberculosis treatment by people over age 60 in Kampala, Uganda. PLoS One, 2018, 13(12): e0208390. doi:10.1371/journal.pone.0208390.
[59]	Osei E, Der J, Owusu R, et al. The burden of HIV on Tuberculosis patients in the Volta region of Ghana from 2012 to 2015: implication for Tuberculosis control. BMC Infect Dis, 2017, 17(1): 504. doi:10.1186/s12879-017-2598-z. pmid: 28724359
[60]	汤后林, 金怡晨, 吕繁. 我国老年人群艾滋病防控现状与挑战. 中华流行病学杂志, 2023, 44(11): 1669-1672. doi:10.3760/cma.j.cn112338-20230629-00402.
[61]	Moir S, Chun TW, Fauci AS. Pathogenic mechanisms of HIV disease. Annu Rev Pathol, 2011, 6: 223-248. doi:10.1146/annurev-pathol-011110-130254. pmid: 21034222
[62]	Suarez GV, Angerami MT, Vecchione MB, et al. HIV-TB coinfection impairs CD8⁺ T-cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses. Eur J Immunol, 2015, 45(9): 2529-2541. doi:10.1002/eji.201545545.
[63]	Mancino G, Placido R, Bach S, et al. Infection of human monocytes with Mycobacterium tuberculosis enhances human immunodeficiency virus type 1 replication and transmission to T cells. J Infect Dis, 1997, 175(6): 1531-1535. doi:10.1086/516494. pmid: 9180201
[64]	Sáez-Cirión A, Manel N. Immune Responses to Retroviruses. Annu Rev Immunol, 2018, 36: 193-220. doi:10.1146/annu-rev-immunol-051116-052155. pmid: 29328787
[65]	Hawker JI, Bakhshi SS, Ali S, et al. Ecological analysis of ethnic differences in relation between tuberculosis and poverty. BMJ, 1999, 319(7216): 1031-1034. doi:10.1136/bmj.319.7216.1031. pmid: 10521193
[66]	Jackson S, Sleigh AC, Wang GJ, et al. Poverty and the economic effects of TB in rural China. Int J Tuberc Lung Dis, 2006, 10(10): 1104-1110. pmid: 17044202
[67]	王国杰, Sleigh A, 周刚, 等. 成年人肺结核病的非生物危险因素病例对照研究. 中华流行病学杂志, 2005, 26(2): 92-96. doi:10.3760/j.issn:0254-6450.2005.02.004.
[68]	Boccia D, Hargreaves J, De Stavola BL, et al. The association between household socioeconomic position and prevalent tuberculosis in Zambia: a case-control study. PLoS One, 2011, 6(6): e20824. doi:10.1371/journal.pone.0020824.
[69]	Singh SK, Kashyap GC, Puri P. Potential effect of household environment on prevalence of tuberculosis in India: evidence from the recent round of a cross-sectional survey. BMC Pulm Med, 2018, 18(1): 66. doi:10.1186/s12890-018-0627-3. pmid: 29724218
[70]	祖丽娅·沙塔尔. 乌鲁木齐市老年人肺结核影响因素的病例对照研究. 乌鲁木齐: 新疆医科大学, 2017. doi:10.7666/d.D01195813.
[71]	徐曼. 大气污染物暴露与结核病进程相关结局的关联性研究. 武汉: 华中科技大学, 2022.
[72]	Zhang K, Wang X, Tu J, et al. The interplay between depression and tuberculosis. J Leukoc Biol, 2019, 106(3): 749-757. doi:10.1002/JLB.MR0119-023R.
[73]	赵新宇, 邓墨瑶, 刘公利, 等. 哈尔滨地区成年人肺结核危险因素调查研究. 中国初级卫生保健, 2017, 31(7): 62-65. doi:10.3969/j.issn.1001-568X.2017.07.0025.
[74]	马艳, 高微微. 老年结核病防治现状与展望. 结核病与肺部健康杂志, 2018, 7(3): 161-166. doi:10.3969/j.issn.2095-3755.2018.03.003.