Co-morbidity research progress of tuberculosis and depression

doi:10.19982/j.issn.1000-6621.20230381

Abstract

Abstract:

Tuberculosis and depression are both global public health concerns. There is a complex interplay between tuberculosis and depression. This review focuses on the literature on prevalence, risk factors, and mechanisms of interaction between these two diseases. We also summarize the progress on the diagnostic and therapeutic strategies for patients with both tuberculosis and depression. By reviewing the research progression in these comorbidities, we aim to extend our understanding on their underlying interaction, which is of great importance for formulating effective strategies on clinical management of these patients, and pointing out the avenues of future research.

Key words: Tuberculosis, Depressive disorder, Comorbidity, Research

CLC Number:

R52
R749

Sun Qingfeng, Li Haoran, Pang Yu, Gao Mengqiu. Co-morbidity research progress of tuberculosis and depression[J]. Chinese Journal of Antituberculosis, 2024, 46(1): 106-111. doi: 10.19982/j.issn.1000-6621.20230381

Figures/Tables 2

References 56

[1]	World Health Organization.Global tuberculosis report 2023. Geneva: World Health Organization, 2023.
[2]	World Health Organization. Depression and other common mental disorders global health estimates. Geneva: World Health Organization, 2017.
[3]	傅小兰, 张侃, 陈雪峰, 等. 中国国民心理健康发展报告(2021—2022). 北京: 社会科学文献出版社, 2023.
[4]	World Health Organization. The global burden of disease. 2004 update. Geneva: World Health Organization, 2008.
[5]	祝春素, 连至炜, 崔一民. 中国中老年人抑郁和慢性病的关联. 北京大学学报(医学版), 2023, 55(4): 606-611. doi:10.19723/j.issn.1671-167X.2023.04.006.
[6]	Frank P, Batty GD, Pentti J, et al. Association Between Depression and Physical Conditions Requiring Hospitalization. JAMA Psychiatry, 2023, 80(7): 690-699. doi:10.1001/jamapsychiatry.2023.0777. pmid: 37133850
[7]	Boing AF, Melo GR, Boing AC, et al. Association between depression and chronic diseases: results from a population-based study. Rev Saude Publica, 2012, 46(4): 617-623. doi:10.1590/s0034-89102012005000044.
[8]	Mason PH, Sweetland AC, Fox GJ, et al. Tuberculosis and mental health in the Asia-Pacific. Australas Psychiatry, 2016, 24(6): 553-555. doi:10.1177/1039856216649770. pmid: 27206468
[9]	Vega P, Sweetland A, Acha J, et al. Psychiatric issues in the management of patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis, 2004, 8(6): 749-759. pmid: 15182146
[10]	Westaway MS, Wolmarans L. Depression and self-esteem: rapid screening for depression in black, low literacy, hospitalized tuberculosis patients. Soc Sci Med, 1992, 35(10):1311-1315. doi:10.1016/0277-9536(92)90184-r. pmid: 1439914
[11]	王琳, 侯黎莉, 郭影, 等. 肺结核患者焦虑和抑郁状态及其影响因素. 国际护理学杂志, 2018, 37(20): 2844-2849. doi:10.3760/cma.j.issn.1673-4351.2018.20.035.PH.
[12]	王秀军, 高宁, 张小云, 等. 耐药肺结核患者焦虑抑郁状况与社会支持水平的相关性分析.中华现代护理杂志, 2013, 48(36): 4493-4494, 4495. doi:10.3760/cma.j.issn.1674-2907.2013.36.019.
[13]	Liu X, Bai X, Ren R, et al. Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study. Front Psychiatry, 2022, 13: 985823. doi:10.3389/fpsyt.2022.985823.
[14]	Koyanagi A, Vancampfort D, Carvalho AF, et al. Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries. BMC Med, 2017, 15(1): 209. doi:10.1186/s12916-017-0975-5. pmid: 29179720
[15]	Duko B, Bedaso A, Ayano G. The prevalence of depression among patients with tuberculosis: a systematic review and meta-analysis. Ann Gen Psychiatry, 2020, 19: 30. doi:10.1186/s12991-020-00281-8.
[16]	McQuistion HL, Colson P, Yankowitz R, et al. Tuberculosis infection among people with severe mental illness. Psychiatr Serv, 1997, 48(6): 833-835. doi:10.1176/ps.48.6.833.
[17]	Saez H, Valencia E, Conover S, et al. Tuberculosis and HIV among mentally ill men in a New York City shelter. Am J Public Health, 1996, 86(9): 1318-1319. doi:10.2105/ajph.86.9.1318. pmid: 8806388
[18]	de Araújo GS, Pereira SM, dos Santos DN, et al. Common mental disorders associated with tuberculosis: a matched case-control study. PLoS One, 2014, 9(6): e99551. doi:10.1371/journal.pone.0099551.
[19]	Oh KH, Choi H, Kim EJ, et al. Depression and risk of tuberculosis: a nationwide population-based cohort study. Int J Tuberc Lung Dis, 2017, 21(7): 804-809. doi:10.5588/ijtld.17.0038. pmid: 28633706
[20]	Dai Y, Xie L, Wang X, et al. Depression increases the risk of tuberculosis: Preliminary observations. J Infect, 2021, 83(4): 496-522. doi:10.1016/j.jinf.2021.07.026. pmid: 34371073
[21]	Shen R, Zong K, Liu J, et al. Risk Factors for Depression in Tuberculosis Patients: A Meta-Analysis. Neuropsychiatr Dis Treat, 2022, 18: 847-866. doi:10.2147/NDT.S347579.
[22]	Basham CA, Karim ME, Cook VJ, et al. Tuberculosis-associated depression: a population-based cohort study of people immigrating to British Columbia, Canada, 1985-2015. Ann Epidemiol, 2021, 63: 7-14. doi:10.1016/j.annepidem.2021.06.002.
[23]	Berg J, Nyamathi A, Christiani A, et al. Predictors of screening results for depressive symptoms among homeless adults in Los Angeles with latent tuberculosis. Res Nurs Health, 2005, 28(3): 220-229. doi:10.1002/nur.20074. pmid: 15884031
[24]	Furin JJ, Mitnick CD, Shin SS, et al. Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosis. Int J Tuberc Lung Dis, 2001, 5(7): 648-655. pmid: 11467371
[25]	Doherty AM, Kelly J, McDonald C, et al. A review of the interplay between tuberculosis and mental health. Gen Hosp Psychiatry, 2013, 35(4): 398-406. doi:10.1016/j.genhosppsych.2013.03.018.
[26]	Helmy B. Side effects of cycloserine. Scand J Respir Dis Suppl, 1970, 71: 220-225.
[27]	Trenton AJ, Currier GW. Treatment of Comorbid Tuberculosis and Depression. Prim Care Companion J Clin Psychiatry, 2001, 3(6): 236-243. doi:10.4088/pcc.v03n0610.
[28]	Pachi A, Bratis D, Moussas G, et al. Psychiatric morbidity and other factors affecting treatment adherence in pulmonary tuberculosis patients. Tuberc Res Treat, 2013, 2013: 489865. doi:10.1155/2013/489865.
[29]	Cao Y, Yu C, Wu Y. Incidence rate of depression as an adverse effect of multidrug-resistant tuberculosis treatment. J Infect, 2019, 79(1): 61-74. doi:10.1016/j.jinf.2019.04.001. pmid: 30978360
[30]	Davis L, Uezato A, Newell JM, et al. Major depression and comorbid substance use disorders. Curr Opin Psychiatry, 2008, 21(1):14-18. doi:10.1097/YCO.0b013e3282f32408.
[31]	Sweetland AC, Kritski A, Oquendo MA, et al. Addressing the tuberculosis-depression syndemic to end the tuberculosis epidemic. Int J Tuberc Lung Dis, 2017, 21(8): 852-861. doi:10.5588/ijtld.16.0584. pmid: 28786792
[32]	Zunszain PA, Anacker C, Cattaneo A, et al. Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35(3): 722-729. doi:10.1016/j.pnpbp.2010.04.011.
[33]	Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. Lancet Oncol, 2004, 5(10): 617-625. doi:10.1016/S1470- 2045(04)01597-9.
[34]	Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry, 2009, 65(9): 732-741. doi:10.1016/j.biopsych.2008.11.029.
[35]	Kaufmann SH, Dorhoi A. Inflammation in tuberculosis: intera-ctions, imbalances and interventions. Curr Opin Immunol, 2013, 25(4): 441-449. doi:10.1016/j.coi.2013.05.005. pmid: 23725875
[36]	Li Y, Xiao B, Qiu W, et al. Altered expression of CD4⁺CD25⁺ regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder. J Affect Disord, 2010, 124(1/2): 68-75. doi:10.1016/j.jad.2009.10.018.
[37]	Patas K, Willing A, Demiralay C, et al. T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder. Front Immunol, 2018, 9: 291. doi:10.3389/fimmu.2018.00291. pmid: 29515587
[38]	Haapakoski R, Ebmeier KP, Alenius H, et al. Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances. Prog Neuropsychopharmacol Biol Psychiatry, 2016, 66: 63-72. doi:10.1016/j.pnpbp.2015.11.012.
[39]	Rameshwaram NR, Singh P, Ghosh S, et al. Lipid metabolism and intracellular bacterial virulence: key to next-generation therapeutics. Future Microbiol, 2018, 13: 1301-1328. doi:10.2217/fmb-2018-0013. pmid: 30256124
[40]	Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol, 2002, 20: 197-216. doi:10.1146/annurev.immunol.20.083001.084359. pmid: 11861602
[41]	Rosenberger K, Derkow K, Dembny P, et al. The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration. J Neuroinflammation, 2014, 11: 166. doi:10.1186/s12974-014-0166-7.
[42]	Kinsella RJ, Fitzpatrick DA, Creevey CJ, et al. Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication. Proc Natl Acad Sci U S A, 2003, 100(18):10320-10325. doi:10.1073/pnas.1737230100.
[43]	中华人民共和国国家卫生和计划生育委员会. WS 288—2017肺结核诊断. 2017-11-09.
[44]	陈素珍, 袁勇贵. 躯体疾病和抑郁障碍共病的诊断、评估及治疗原则. 医学与哲学, 2013, 34(4): 23-27.
[45]	Aydin IO, Uluşahin A. Depression, anxiety comorbidity, and disability in tuberculosis and chronic obstructive pulmonary disease patients: applicability of GHQ-12. Gen Hosp Psychiatry, 2001, 23(2): 77-83. doi:10.1016/s0163-8343(01)00116-5.
[46]	李凌江, 马辛. 中国抑郁障碍防治指南. 北京: 中华医学电子音像出版社, 2015.
[47]	Van Der Walt M, Keddy KH. The Tuberculosis-Depression Syndemic and Evolution of Pharmaceutical Therapeutics: From Ancient Times to the Future. Front Psychiatry, 2021, 12: 617751. doi:10.3389/fpsyt.2021.617751.
[48]	Shankaran D, Singh A, Dawa S, et al. The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy. Elife, 2023, 12: e64834. doi:10.7554/eLife.64834.
[49]	Strayhorn VA, Baciewicz AM, Self TH. Update on rifampin drug interactions, Ⅲ. Arch Intern Med, 1997, 157(21): 2453-2458. pmid: 9385296
[50]	Markowitz JS, DeVane CL. Rifampin-induced selective serotonin reuptake inhibitor withdrawal syndrome in a patient treated with sertraline. J Clin Psychopharmacol, 2000, 20(1): 109-10. doi:10.1097/00004714-200002000-00023. pmid: 10653222
[51]	Chen J, Raymond K. Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob, 2006, 5: 3. doi:10.1186/1476-0711-5-3.
[52]	Preskorn SH. Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism. Clin Pharmacokinet, 1997, 32 Suppl 1:1-21. doi:10.2165/00003088-199700321-00003. pmid: 9068931
[53]	Caccia S. Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications. Clin Pharmacokinet, 1998, 34(4): 281-302. doi:10.2165/00003088-199834040-00002. pmid: 9571301
[54]	Janmeja AK, Das SK, Bhargava R, et al. Psychotherapy improves compliance with tuberculosis treatment. Respiration, 2005, 72(4): 375-380. doi:10.1159/000086251. pmid: 16088280
[55]	Tola HH, Shojaeizadeh D, Tol A, et al. Psychological and Educational Intervention to Improve Tuberculosis Treatment Adherence in Ethiopia Based on Health Belief Model: A Cluster Randomized Control Trial. PLoS One, 2016, 11(5): e0155147. doi:10.1371/journal.pone.0155147.
[56]	Zhang K, Wang X, Tu J, et al. The interplay between depression and tuberculosis. J Leukoc Biol, 2019, 106(3): 749-757. doi:10.1002/JLB.MR0119-023R.

量表名称	英文全称	英文缩写	适用人群	评定方式	主要用途
汉密尔顿抑郁量表	Hamilton depression scale	HAMD	抑郁症患者	他评	评估抑郁症状严重程度及抗抑郁药疗效
蒙哥马利-艾斯伯格抑郁量表	Montgomery-Asberg depression rating scale	MADRS	抑郁症患者	他评	评估抑郁症状严重程度及抗抑郁药疗效
医院焦虑抑郁量表	hospital anxiety and depression scale	HADS	医院躯体疾病患者	自评	筛查
抑郁自评量表	self-rating depression scale	SDS	普通人群	自评	筛查及评估抑郁症状严重程度
贝克抑郁量表	Beck depression inventory	BDI	普通人群	自评	筛查及评估抑郁症状严重程度
九项抑郁症状自评量表	patient health questionnaire-9	PHQ-9	普通人群	自评	筛查及评估抑郁症状严重程度
流调中心用抑郁量表	center for epidemiologic studies depression scale	CES-D	普通人群	自评	流行病学研究
老年抑郁量表	geriatric depression scale	GDS	老年人	自评	筛查
爱丁堡产后抑郁量表	Edinburgh postnatal depression scale	EPDS	产妇	自评	筛查
儿童抑郁量表	children’s depression inventory	CDI	7~17岁儿童	自评	筛查

抗结核药物	抗抑郁药物	相互作用
异烟肼	帕罗西汀	帕罗西汀由CYP2D6代谢,CYP2D6受异烟肼的影响最小,潜在的药物相互作用并不显著^[52-53]
异烟肼	舍曲林	可提高巨噬细胞中异烟肼的杀菌活性,但更多人体试验证据或作用机制尚不明确^[48]
异烟肼	西酞普兰	西酞普兰主要由CYP2C19和CYP3A4代谢,这两种酶会受到异烟肼的抑制^[52]
异烟肼	氟伏沙明	氟伏沙明抑制CYP1A2和CYP2C19,可能还有CYP3A3/4,以上均被异烟肼抑制^[52]
利福平	去甲替林	利福平是许多CYP450酶的有效诱导剂,与去甲胎蛋白相互作用,会降低其血药浓度^[25]
利福平	舍曲林	一份舍曲林和利福平联合用药的病例报告显示,由于利福平诱导CYP450系统而引起舍曲林血药浓度降低,最终导致治疗失败^[50]
利福平	安非他酮	利福平对CYP2B6的诱导作用可能会导致安非他酮代谢增加,但还需要进一步的研究来支持这一观点^[51]
利奈唑胺	选择性5-羟色胺再摄取抑制剂	利奈唑胺是恶唑烷酮类抗生素,也是一种单胺氧化酶抑制剂,与西酞普兰、艾司西酞普兰、舍曲林、氟西汀、帕罗西汀、文拉法辛和度洛西汀等选择性血清素再摄取抑制剂联合使用时可能导致血清素综合征^[25]