Abstract:

Currently, great progress has been made in tuberculosis (TB) diagnosis, treatment and prevention; however, there is still a long way to go. In recent years, large-scale cohort studies and biological sample library resources have led to continuous breakthroughs in disease research and TB-related translational medicine. Diagnostic technology and drug development ideas and approval standards have also begun to change, and related products have gradually been applied in clinic, improving the level of precise prevention, diagnosis, and treatment. In this review, we present the current dilemma based on the current situation of TB diagnosis and treatment, elaborate the concept TB prevention and treatment based on the concept of precision medicine, emphasize the role of medical research-based transformation in the accurate diagnosis and treatment of TB, as well as the dual-path transformation of clinical medicine and public health. Finally, on the road to TB translational medicine, it is proposed that, attention should be paid to the cultivation of comprehensive, innovative and high-level medical talents, and establish a policy-oriented guarantee system to guide the orderly development of precision medicine and medical research transformation.

Key words: Tuberculosis, Interdisciplinary communication, Cohort studies