Progress in the identification of Mycobacterium tuberculosis antigenic proteins in clinical specimens

doi:10.19982/j.issn.1000-6621.20220312

Abstract

Abstract:

Tuberculosis (TB) is a serious respiratory disease caused by Mycobacterium tuberculosis (MTB) infection. The spread of TB is hidden, and it is difficult to prevent and control. The current rapid detection technology of TB has certain shortcomings and new diagnostic technology is urgently needed. Antigen detection technology of TB is widely applicable, simple, rapid and accurate. However, no target with good and stable detection effect has been found, and even for the same antigen target, the detection efficiency of different studies varies greatly. Therefore, we reviewed the detection status of antigenic proteins in various clinical specimens confirmed by different identification methods and experimental studies, to reconsider the status and content of MTB antigens in clinical specimens, and improve the method of antigen discovery and identification, so as to provide the theoretical reference for the development of diagnostic technology for tuberculosis antigens.

Key words: Mycobacterium tuberculosis, Antigen, immunology, Biological assay, Review literature as topic

CLC Number:

R378.91
R392

Sheng Gang, Chu Hongqian, Liu Dingyi, Sun Zhaogang. Progress in the identification of Mycobacterium tuberculosis antigenic proteins in clinical specimens[J]. Chinese Journal of Antituberculosis, 2022, 44(12): 1363-1368. doi: 10.19982/j.issn.1000-6621.20220312

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