Abstract: Objective To evaluate and compare 4 reports of tuberculosis drug resistance surveillance of He’nan,Shandong,Zhejiang and Guangdong province.Methods According to the guidelines of WHO/IUATLD drug resistance surveillance of tuberculosis project, the items of every report was checked and analyzed.Results There were difference on estimation of sample size,technique indexes which be used in laborat ories, the definitions of primary and acquired drug resistance among four reports.Conclusion Only the standardization of Methods be us ed,the Results will be comparable among participating laboratories. It is impor tant to establish surveillance of drug resistance system in nationwide.

Key words: Tuberculosis, Drug resistance, Surveillance